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Titolo:
CAROTID ATHEROSCLEROSIS IN PREMENOPAUSAL AND POSTMENOPAUSAL WOMEN ANDITS ASSOCIATION WITH RISK-FACTORS MEASURED AFTER MENOPAUSE
Autore:
SUTTONTYRRELL K; LASSILA HC; MEILAHN E; BUNKER C; MATTHEWS KA; KULLER LH;
Indirizzi:
UNIV PITTSBURGH,GRAD SCH PUBL HLTH,DEPT EPIDEMIOL,230 DESOTO ST PITTSBURGH PA 15261 UNIV PITTSBURGH,GRAD SCH PUBL HLTH,DEPT PSYCHIAT PITTSBURGH PA 15261 LONDON SCH HYG & TROP MED LONDON WC1 ENGLAND
Titolo Testata:
Stroke
fascicolo: 6, volume: 29, anno: 1998,
pagine: 1116 - 1121
SICI:
0039-2499(1998)29:6<1116:CAIPAP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORONARY HEART-DISEASE; DENSITY LIPOPROTEIN CHOLESTEROL; ARTERIAL-WALL THICKNESS; INTIMA-MEDIA THICKNESS; MIDDLE-AGED WOMEN; CARDIOVASCULAR-DISEASE; POPULATION; ULTRASOUND; BEHAVIOR; SMOKING;
Keywords:
ATHEROSCLEROSIS; CAROTID ARTERY DISEASES; EPIDEMIOLOGY; WOMEN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
K. Suttontyrrell et al., "CAROTID ATHEROSCLEROSIS IN PREMENOPAUSAL AND POSTMENOPAUSAL WOMEN ANDITS ASSOCIATION WITH RISK-FACTORS MEASURED AFTER MENOPAUSE", Stroke, 29(6), 1998, pp. 1116-1121

Abstract

Background and Purpose-In women, symptoms of coronary artery disease are delayed by 10 to 15 years in comparison with men, most likely because of the protective effect of ovarian hormones. This report comparesthe prevalence and degree of carotid atherosclerosis between 292 premenopausal women and 294 women at 5 to 8 years after menopause. Methods-Scans were performed in the same laboratory over the same time periodfor both groups. Intima-media thickness (IMT) was averaged across thecommon, bulb, and internal carotids. The plaque index summarized degree of focal plaque based on the size and number of plaques throughout both carotid systems. Results-Mean IMT was 0.69 mm for premenopausal women and 0.77 mm for postmenopausal women (P<0.001), Prevalence of plaque was 25% among premenopausal women and 54% among postmenopausal women (P<0.001), In both premenopausal and postmenopausal women, risk factors measured before menopause were associated with carotid atherosclerosis. Premenopausal risk factors independently associated with IMT were higher pulse pressure (P<0.001), triglycerides (P=0.002), body massindex (P<0.001), and study group (a surrogate for both age and menopausal status; P<0.001), Premenopausal risk factors independently associated with focal plaque were ever smoking (P=0.002), higher pulse pressure (P=0.028), higher LDL (P=0.003), age at baseline (P=0.050), and study group (P<0.001), Conclusions-Subclinical carotid atherosclerosis can be observed in middle-aged women. Risk factors measured before menopause are clearly associated with subclinical disease measured both concurrently and at 5 to 8 years after menopause.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 10:43:39