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Titolo:
LONG-TERM L-ARGININE SUPPLEMENTATION IMPROVES SMALL-VESSEL CORONARY ENDOTHELIAL FUNCTION IN HUMANS
Autore:
LERMAN A; BURNETT JC; HIGANO ST; MCKINLEY LJ; HOLMES DR;
Indirizzi:
MAYO CLIN & MAYO FDN,DIV CARDIOVASC DIS,200 1ST ST SW ROCHESTER MN 55905 MAYO CLIN & MAYO FDN,DEPT INTERNAL MED ROCHESTER MN 55905
Titolo Testata:
Circulation
fascicolo: 21, volume: 97, anno: 1998,
pagine: 2123 - 2128
SICI:
0009-7322(1998)97:21<2123:LLSISC>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
DIETARY L-ARGININE; NITRIC-OXIDE; HYPERCHOLESTEROLEMIC RABBIT; ARTERY DISEASE; DEPENDENT VASODILATION; NO PRODUCTION; DYSFUNCTION; ATHEROSCLEROSIS; AORTA; ACETYLCHOLINE;
Keywords:
VESSELS; ENDOTHELIUM; ARGININE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
A. Lerman et al., "LONG-TERM L-ARGININE SUPPLEMENTATION IMPROVES SMALL-VESSEL CORONARY ENDOTHELIAL FUNCTION IN HUMANS", Circulation, 97(21), 1998, pp. 2123-2128

Abstract

Background-Coronary endothelial dysfunction is characterized by an imbalance between endothelium-derived vasodilating and vasoconstricting factors and coronary vasoconstriction in response to the endothelium-dependent vasodilator acetylcholine. Thus, the present double-blind, randomized study was designed to test the hypothesis that long-term, 6-month supplementation of L-arginine, the precursor of the endothelium-derived vasodilator NO, reverses coronary endothelial dysfunction to acetylcholine in humans with nonobstructive coronary artery disease. Methods and Results-Twenty-six patients without significant coronary artery disease on coronary angiography and intravascular ultrasound were blindly randomized to either oral L-arginine or placebo, 3 g TID. Endothelium-dependent coronary blood flow reserve to acetylcholine (10(-6) to 10(-4) mol/L) was assessed at baseline and after 6 months of therapy. There was no difference between the two study groups in clinical characteristics or in the coronary blood flow in the response to acetylcholine at baseline. After 6 months, the coronary blood flow in response to acetylcholine in the subjects who were taking L-arginine increased compared with the placebo group (149+/-20% versus 6+/-9%, P<0.05), This was associated with a decrease in plasma endothelin concentrationsand an improvement in patients' symptoms scores in the L-arginine treatment group compared with the placebo group. Conclusions-Long-term oral L-arginine supplementation for 6 months in humans improves coronarysmall-vessel endothelial function in association with a significant improvement in symptoms and a decrease in plasma endothelin concentrations. This study proposes a role for L-arginine as a therapeutic optionfor patients with coronary endothelial dysfunction and nonobstructivecoronary artery disease.

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Documento generato il 05/07/20 alle ore 13:00:54