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Titolo:
DOPAMINE PRODUCED BY THE STOMACH MAY ACT AS A PARACRINE AUTOCRINE HORMONE IN THE RAT/
Autore:
MEZEY E; EISENHOFER G; HANSSON S; HUNYADY B; HOFFMAN BJ;
Indirizzi:
NINCDS,BASIC NEUROSCI BRANCH,BLDG 36,3D06 BETHESDA MD 20892 NINCDS,CLIN NEUROSCI BRANCH BETHESDA MD 20892 NIMH,LAB CELLULAR & MOL REGULAT BETHESDA MD 20892 NIMH,PEOPLE INVESTIGATING GENES BETHESDA MD 20892 DEPT MED 1 PECS HUNGARY
Titolo Testata:
Neuroendocrinology
fascicolo: 5, volume: 67, anno: 1998,
pagine: 336 - 348
SICI:
0028-3835(1998)67:5<336:DPBTSM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
MUCOSAL BLOOD-FLOW; VESICULAR MONOAMINE TRANSPORTER; GASTRIC-ACID SECRETION; GASTROINTESTINAL-TRACT; DIFFERENTIAL EXPRESSION; BICARBONATE SECRETION; MOLECULAR-CLONING; UPTAKE INHIBITOR; PORCINE JEJUNUM; NERVOUS-SYSTEM;
Keywords:
STOMACH; SYMPATHECTOMY; MONOAMINE TRANSPORTERS; PARIETAL CELLS; CATECHOLAMINES; PERIPHERAL NEUROENDOCRINOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
87
Recensione:
Indirizzi per estratti:
Citazione:
E. Mezey et al., "DOPAMINE PRODUCED BY THE STOMACH MAY ACT AS A PARACRINE AUTOCRINE HORMONE IN THE RAT/", Neuroendocrinology, 67(5), 1998, pp. 336-348

Abstract

Dopamine (DA) has been suggested to be a protective factor in the gastrointestinal tract but neither a source of DA nor its exact targets of action have been identified. In this study, we demonstrate high levels of DA (and DOPA) which persist after chemical sympathectomy in the gastric juice of rats. Immunostaining and in situ hybridization histochemistry reveal the presence of tyrosine hydroxylase (TH), DA transporter and vesicular monamine transporters in the acid-producing parietalcells. Like DA, TH enzyme activity remains after chemical sympathectomy. We also demonstrate active reuptake and storage of DA that indicates a regulated release of this neurohormone from parietal cells. DA Dib receptor mRNA is the most abundant DA receptor subtype in gastric and duodenal epithelium. Therefore, we suggest that selective DA Dib receptor agonists may be useful adjuncts in the treatment of duodenal andgastric ulcers. Gastric epithelia possess the hallmarks of functionalDA neuroendocrine cells, suggesting that DA has an important role in self-protective mechanisms of the gastrointestinal tract. These findings should allow elucidation of DA role in normal and disease states inthe stomach and duodenum.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:54:50