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Titolo:
CEFTAZIDIME AND AZTREONAM RESISTANCE IN PROVIDENCIA-STUARTII - CHARACTERIZATION OF A NATURAL TEM-DERIVED EXTENDED-SPECTRUM BETA-LACTAMASE, TEM-60
Autore:
FRANCESCHINI N; PERILLI M; SEGATORE B; SETACCI D; AMICOSANTE G; MAZZARIOL A; CORNAGLIA G;
Indirizzi:
UNIV AQUILA,DIPARTIMENTO SCI & TECNOL BIOMED,LOC COPPITO I-67010 LAQUILA ITALY UNIV AQUILA,DIPARTIMENTO SCI & TECNOL BIOMED I-67010 LAQUILA ITALY UNIV VERONA,IST MICROBIOL I-37134 VERONA ITALY
Titolo Testata:
Antimicrobial agents and chemotherapy
fascicolo: 6, volume: 42, anno: 1998,
pagine: 1459 - 1462
SICI:
0066-4804(1998)42:6<1459:CAARIP>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
CLASSIFICATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
N. Franceschini et al., "CEFTAZIDIME AND AZTREONAM RESISTANCE IN PROVIDENCIA-STUARTII - CHARACTERIZATION OF A NATURAL TEM-DERIVED EXTENDED-SPECTRUM BETA-LACTAMASE, TEM-60", Antimicrobial agents and chemotherapy, 42(6), 1998, pp. 1459-1462

Abstract

A plasmid-encoded beta-lactamase produced from a clinical strain of Providencia stuartii has been purified and characterized. The gene coding for the beta-lactamase was cloned and sequenced. It appears to be anew natural TEM-derived enzyme, named TEM-60. Point mutations (Q39K, L51P, E104K, and R164S) are present with respect to the TEM-1 enzyme; the mutation L51P has never been previously reported, with the exception of the chromosomally encoded extended-spectrum beta-lactamase PER-1. Kinetic parameters relative to penicillins, cephalosporins, and monobactams other than mechanism-based inactivators were related to the invitro susceptibility phenotype.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 07:17:25