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Titolo:
MOXIFLOXACIN IN THE THERAPY OF EXPERIMENTAL PNEUMOCOCCAL MENINGITIS
Autore:
SCHMIDT H; DALHOFF A; STUERTZ K; TROSTDORF F; CHEN V; SCHNEIDER O; KOHLSDORFER C; BRUCK W; NAU R;
Indirizzi:
UNIV GOTTINGEN,DEPT NEUROL,ROBERT KOCH STR 40 D-37075 GOTTINGEN GERMANY UNIV GOTTINGEN,DEPT NEUROL D-37075 GOTTINGEN GERMANY UNIV GOTTINGEN,DEPT NEUROPATHOL D-37075 GOTTINGEN GERMANY BAYER AG D-5600 WUPPERTAL GERMANY
Titolo Testata:
Antimicrobial agents and chemotherapy
fascicolo: 6, volume: 42, anno: 1998,
pagine: 1397 - 1401
SICI:
0066-4804(1998)42:6<1397:MITTOE>2.0.ZU;2-X
Fonte:
ISI
Lingua:
ENG
Soggetto:
BETA-LACTAM ANTIBIOTICS; STREPTOCOCCUS-PNEUMONIAE; CEREBROSPINAL-FLUID; MENINGEAL INFLAMMATION; ESCHERICHIA-COLI; PENICILLIN-RESISTANT; CIPROFLOXACIN; CEFTRIAXONE; CEFOTAXIME; INDUCTION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
H. Schmidt et al., "MOXIFLOXACIN IN THE THERAPY OF EXPERIMENTAL PNEUMOCOCCAL MENINGITIS", Antimicrobial agents and chemotherapy, 42(6), 1998, pp. 1397-1401

Abstract

The activity of moxifloxacin (BAY 12-8039) against a Streptococcus pneumoniae type 3 strain (MIC and minimum bactericidal concentration [MBC] of moxifloxacin, 0.06 and 0.25 mu g/ml, respectively; MIC and MBC of ceftriaxone, 0.03 and 0.06 mu g/ml, respectively) was determined in vitro and in a rabbit model of meningitis. Despite comparable bactericidal activity, 10 mu g of moxifloxacin per mi released lipoteichoic and teichoic acids less rapidly than 10 mu g of ceftriaxone per mi in vitro. Against experimental meningitis, 10 mg of moxifloxacin per kg of body weight per mi reduced the bacterial titers in cerebrospinal fluid(CSF) almost as rapidly as ceftriaxone did (mean +/- standard deviation, -0.32 +/- 0.14 versus -0.39 +/- 0.11 Delta log CFU/ml/h), The activity of moxifloxacin could be described by a sigmoid dose-response curve with a maximum effect of -0.33 Delta logCFU/ml/h and with a dosage of 1.4 mg/kg/h producing a half-maximal effect, Maximum tumor necrosisfactor activity in CSF was observed later with moxifloxacin than withceftriaxone (5 versus 2 h after the initiation of treatment). At 10 mg/kg/h, the concentrations of moxifloxacin in CSF were 3.8 +/- 1.2 mu g/ml. Adjunctive treatment with dexamethasone at 1 mg/kg prior to the initiation of antibiotic treatment only marginally reduced the concentrations of moxifloxacin in CSF (3.3 +/- 0.6 mu g/ml), In conclusion, moxifloxacin may qualify for use in the treatment of S. pneumoniae meningitis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/07/20 alle ore 20:36:18