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Titolo:
TRISOMY-12 AND T(14-18) IN B-CELL CHRONIC LYMPHOCYTIC-LEUKEMIA
Autore:
KOJIMA K; TANIWAKI M; YOSHINO T; KATAYAMA Y; SUNAMI K; FUKUDA S; OMOTO E; HARADA M; SEZAKI T;
Indirizzi:
EHIME PREFECTURAL CENT HOSP,DIV HEMATOL,83 KASUGA CHO MATSUYAMA EHIME790 JAPAN NATL OKAYAMA HOSP,DIV HEMATOL OKAYAMA JAPAN
Titolo Testata:
International journal of hematology
fascicolo: 2, volume: 67, anno: 1998,
pagine: 199 - 203
SICI:
0925-5710(1998)67:2<199:TATIBC>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
IN-SITU HYBRIDIZATION; BCL-2; GENE; EXPRESSION; DIFFERENTIATION; TRANSLOCATIONS; REARRANGEMENT; INTERPHASE; CLL;
Keywords:
B-CELL CHRONIC LYMPHOCYTIC LEUKEMIA (B-CLL); TRISOMY 12; T(14-18); MAJOR BREAKPOINT REGION; FLUORESCENCE IN SITU HYBRIDIZATION (FISH);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
K. Kojima et al., "TRISOMY-12 AND T(14-18) IN B-CELL CHRONIC LYMPHOCYTIC-LEUKEMIA", International journal of hematology, 67(2), 1998, pp. 199-203

Abstract

We report a case of B-cell chronic lymphocytic leukemia (B-CLL) in which trisomy 12 and t(14;18)(q32;q21) were simultaneously detected in the same leukemic clone. Southern blot analysis showed that the BCL2/IgJH rearrangement occurred at the major breakpoint region in the hot spot of the BCL2 gene. Double color fluorescence in situ hybridization analysis using multiple probes indicated that clonal B-cells with t(14;18) represented a subpopulation of the total leukemic cells and that trisomy 12 followed t(14;18) as the cytogenetic aberration in the development of B-CLL. Our findings suggests that both the t(14;18) and the trisomy are secondary chromosomal changes in the leukemogenesis of B-CLL. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 15:50:35