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Titolo:
RECOMBINANT-HUMAN-ERYTHROPOIETIN FOR LATE-ONSET ANEMIA AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION
Autore:
FUJIMORI Y; KANAMARU A; SAHEKI K; MORI A; TAKATSUKA H; WADA H; OKADA M; TAMURA S; OKAMOTO T; TAKEMOTO Y; KAKISHITA E; NAGAI K;
Indirizzi:
HYOGO MED UNIV,DEPT INTERNAL MED 2,1-1 MUKOGAWA CHO NISHINOMIYA HYOGO663 JAPAN
Titolo Testata:
International journal of hematology
fascicolo: 2, volume: 67, anno: 1998,
pagine: 131 - 136
SICI:
0925-5710(1998)67:2<131:RFLAAA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INFECTION; TRIAL;
Keywords:
ANEMIA; ERYTHROPOIETIN; BONE MARROW TRANSPLANTATION; GRAFT-VERSUS- HOST DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
Y. Fujimori et al., "RECOMBINANT-HUMAN-ERYTHROPOIETIN FOR LATE-ONSET ANEMIA AFTER ALLOGENEIC BONE-MARROW TRANSPLANTATION", International journal of hematology, 67(2), 1998, pp. 131-136

Abstract

Recombinant human erythropoietin (rHu EPO) has been reported to accelerate early erythroid reconstitution after bone marrow transplantation(BMT). We conducted a pilot study on rHu EPO for late-onset anemia in9 patients after allogeneic BMT. The patients achieved initial erythropoietic recovery (hemoglobin (Hb) range 9.1-13.4, mean 10.8 g/dl), but then developed transplant-related anemia (Hb range 6.3-9.7, mean 8.2g/dl) more than 50 days after BMT. This type of anemia was related tograft-versus-host disease (GVHD), cytomegalovirus infection, and/or impaired EPO secretion. The patients received 3000 or 12000 U of rHu EPO subcutaneously three or seven times weekly. Hb levels increased by more than 2 g/dl in 6 of the 9 patients, but were unchanged in the 3 patients with severe GVHD. These findings suggest that in some cases rHuEPO is effective for the treatment of late-onset anemia after BMT. (C) 1998 Elsevier Science Ireland Ltd. All rights reserved.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/09/20 alle ore 12:09:23