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Titolo:
THE CYCLIN KINASE INHIBITOR P21(WAF1, CIP1) IS INCREASED IN EXPERIMENTAL DIABETIC NEPHROPATHY, POTENTIAL ROLE IN GLOMERULAR HYPERTROPHY
Autore:
KUAN CJ; ALDOUAHJI M; SHANKLAND SJ;
Indirizzi:
UNIV WASHINGTON,MED CTR,DIV NEPHROL,1959 NE PACIFIC ST,BOX 356521 SEATTLE WA 98195 UNIV WASHINGTON,MED CTR,DIV NEPHROL SEATTLE WA 98195
Titolo Testata:
Journal of the American Society of Nephrology
fascicolo: 6, volume: 9, anno: 1998,
pagine: 986 - 993
SICI:
1046-6673(1998)9:6<986:TCKIPC>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTOR-BETA; CELL-CYCLE; RENAL HYPERTROPHY; TGF-BETA; PROLIFERATIVE GLOMERULONEPHRITIS; DEPENDENT KINASES; MESANGIAL CELLS; GENE-EXPRESSION; HIGH GLUCOSE; APOPTOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
C.J. Kuan et al., "THE CYCLIN KINASE INHIBITOR P21(WAF1, CIP1) IS INCREASED IN EXPERIMENTAL DIABETIC NEPHROPATHY, POTENTIAL ROLE IN GLOMERULAR HYPERTROPHY", Journal of the American Society of Nephrology, 9(6), 1998, pp. 986-993

Abstract

High glucose inhibits mesangial cell proliferation in vitro and induces hypertrophy in mesangial cells in culture and in experimental diabetic nephropathy. Cell growth is ultimately controlled at the level of the cell cycle by cell cycle regulatory proteins. Cell cycle progression requires that cyclin-dependent kinases be activated by cyclins, Cyclin kinase inhibitors (CKI) inactivate cyclin-dependent kinases, causing cell cycle arrest. In the current study, high glucose-induced mesangial cell hypertrophy in vitro is shown to be associated with increased levels of the CKI p21, but not p27. In the streptozotocin model of experimental diabetes in the mouse, glomerular hypertrophy was associated with a selective increase in p21 expression, whereas the levels of the CKI p27 and p57 did not change. Unlike many other forms of glomerular injury, diabetic nephropathy was not associated with increased apoptosis. These results support a role for p21 in causing glomerular cell hypertrophy in diabetic nephropathy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/07/20 alle ore 01:13:33