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Titolo:
A ROLE FOR NMDA RECEPTORS IN POSTHYPOXIC FREQUENCY DECLINE IN THE RAT
Autore:
COLES SK; ERNSBERGER P; DICK TE;
Indirizzi:
CASE WESTERN RESERVE UNIV,DEPT MED,DIV PULM & CRIT CARE MED,11100 EUCLID AVE CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT ANAT CLEVELAND OH 44106
Titolo Testata:
American journal of physiology. Regulatory, integrative and comparative physiology
fascicolo: 6, volume: 43, anno: 1998,
pagine: 1546 - 1555
SICI:
0363-6119(1998)43:6<1546:ARFNRI>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
ROSTRAL VENTROLATERAL MEDULLA; NUCLEUS-TRACTUS-SOLITARII; D-ASPARTATE RECEPTORS; H-3 MK-801 BINDING; BRAIN; NEURONS; HYPOXIA; TERMINATION; HYPERCAPNIA; RESPONSES;
Keywords:
RESPIRATION; DIZOCILPINE; HYPOXIA; PENS; TIMING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
S.K. Coles et al., "A ROLE FOR NMDA RECEPTORS IN POSTHYPOXIC FREQUENCY DECLINE IN THE RAT", American journal of physiology. Regulatory, integrative and comparative physiology, 43(6), 1998, pp. 1546-1555

Abstract

Posthypoxic frequency decline (PHFD) refers to the undershoot in respiratory frequency that follows brief hypoxic exposures. Lateral pontine neurons are required for PHFD. The neurotransmitters involved in thecircuit that activate and/or are released by these pontine neurons regulating PHFD are unknown. We hypothesized that N-methyl-D-aspartate (NMDA) receptors are required for PHFD, because of the similarity in respiratory pattern after blocking lateral pontine activity or NMDA receptors. Furthermore, we hypothesized that the location of these NMDA receptors could be visualized by optimizing binding affinity with spermidine. In vagotomized, anesthetized rats (n = 16), cardiorespiratory responses to hypoxia (8% O-2, 30-90 s) were recorded before and after dizocilpine (10 mu g-1 mg/kg iv), and NMDA receptors were mapped with [H-3]dizocilpine (n = 6). Dizocilpine elicited a dose-related effect on PHFD, blocking PHFD at high doses. Resting arterial blood pressure andbreathing frequency decreased with high doses of dizocilpine, but therespiratory response to hypoxia remained intact. Our novel anatomicaldata indicate that NMDA receptors were widespread but distributed differentially in the brain stem. We conclude that NMDA receptors are located in pontine and medullary respiratory-related regions and that PHFD requires NMDA-receptor activation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 02:28:13