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Titolo:
SPECIES-DIFFERENCES IN THE DISTRIBUTION OF BETA-ADRENOCEPTOR SUBTYPESIN BLADDER SMOOTH-MUSCLE
Autore:
YAMAZAKI Y; TAKEDA H; AKAHANE M; IGAWA Y; NISHIZAWA O; AJISAWA Y;
Indirizzi:
KISSEI PHARMACEUT CO LTD,DIV DISCOVERY RES,HOTAKA NAGANO 39983 JAPAN SHINSHU UNIV,SCH MED,DEPT UROL MATSUMOTO NAGANO 390 JAPAN
Titolo Testata:
British Journal of Pharmacology
fascicolo: 3, volume: 124, anno: 1998,
pagine: 593 - 599
SICI:
0007-1188(1998)124:3<593:SITDOB>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
URINARY-BLADDER; BETA-3-ADRENERGIC RECEPTOR; DETRUSOR MUSCLE; MESSENGER-RNA; BETA(3)-ADRENOCEPTOR; RABBIT; RAT; PIG; RELAXATION; AGONIST;
Keywords:
RABBIT DETRUSOR; RAT DETRUSOR; CANINE DETRUSOR; BETA-ADRENOCEPTOR; BETA(3)-ADRENOCEPTOR; SELECTIVE AGONISTS; ANTAGONISTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
Y. Yamazaki et al., "SPECIES-DIFFERENCES IN THE DISTRIBUTION OF BETA-ADRENOCEPTOR SUBTYPESIN BLADDER SMOOTH-MUSCLE", British Journal of Pharmacology, 124(3), 1998, pp. 593-599

Abstract

1 The beta-adrenoceptor (beta-AR) subtypes mediating relaxation of the rabbit, rat and canine detrusors were subjected to functional investigation using selective beta-AR agonists and antagonists. 2 In all three species, isoprenaline, noradrenaline and adrenaline each produced aconcentration-dependent relaxation of the detrusor. The rank order for their relaxing potency was isoprenaline > adrenaline > noradrenalinein rabbits and rats, but isoprenaline > noradrenaline > adrenaline indogs. 3 Dobutamine did not produce relaxation of the detrusors at concentrations that are selective for beta(1)-AR. The selective beta(2)-AR agonist, procaterol, had a more potent relaxing effect on rabbit andrat detrusors than on the canine detrusor. CGP-12177A, a selective beta(3)-AR agonist, was more effective in the rabbit than in the other two species. On the other hand, the relaxing effect of another beta(3)-AR agonist, CL316243, was more pronounced in dogs and rats than in rabbits. 4 CGP-20712A (10(-9) to 10(-7) M), a selective beta(1)-AR antagonist, caused a slight rightward shift of the concentration-relaxation response curve for isoprenaline in the canine detrusor (pA(2) 9.41), but not in the rabbit and rat detrusors. ICI-118,551, a selective beta(2)-AR antagonist, antagonized the isoprenaline-induced relaxation in rabbits (pA(2) 9.45) and rats (pA(2) 9.05), but not in dogs. Bupranolol, a non-selective beta-AR antagonist, caused a rightward shift of the concentration-relaxation curve for isoprenaline in the rabbit (pA(2) 9.32) and rat (pA(2) 8.98). However, higher concentrations (3 x 10(-8) to 10(-5) M) were needed to induce a rightward shift of the curve for isoprenaline in the dog (pA(2) 8.19) than in the other two species. 5. We have confirmed that the distribution of beta-AR subtypes in the detrusor muscle varies significantly from species to species and we provide here the first evidence of the presence of beta(3)-AR in the detrusor. It is suggested that the relaxation induced by adrenoceptor agonists in urinary bladder smooth muscle maybe mediated mainly via beta(2)-AR in rabbits, via both beta(2)- and beta(3)-AR in rats, but mainly via beta(3)-AR in dogs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 03/04/20 alle ore 02:58:43