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Titolo:
DIFFERENT ACTIONS OF CCK ON PANCREATIC AND GASTRIC GROWTH IN THE RAT - EFFECT OF CCKA RECEPTOR BLOCKADE
Autore:
VARGA G; KISFALVI K; PELOSINI I; DAMATO M; SCARPIGNATO C;
Indirizzi:
MAGGIORE UNIV HOSP,INST PHARMACOL I-43100 PARMA ITALY HUNGARIAN ACAD SCI,INST EXPT MED BUDAPEST HUNGARY SEMMELWEIS UNIV MED,DEPT ORAL BIOL H-1085 BUDAPEST HUNGARY UNIV PARMA,SCH MED & DENT,INST PHARMACOL I-43100 PARMA ITALY ROTTA RES LAB SPA MILAN ITALY UNIV NANTES,DEPT GASTROENTEROL & HEPATOL F-44035 NANTES FRANCE
Titolo Testata:
British Journal of Pharmacology
fascicolo: 3, volume: 124, anno: 1998,
pagine: 435 - 440
SICI:
0007-1188(1998)124:3<435:DAOCOP>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
GASTROINTESTINAL GROWTH; ANTAGONIST L-364,718; TROPHIC RESPONSE; SMOOTH-MUSCLE; ACINAR-CELLS; CHOLECYSTOKININ; CERULEIN; SOMATOSTATIN; LORGLUMIDE; CAMOSTATE;
Keywords:
CCK; CCK-RECEPTORS; CCK-ANTAGONISTS; DEXLOXIGLUMIDE; PANCREATIC GROWTH; GASTRIC GROWTH;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
G. Varga et al., "DIFFERENT ACTIONS OF CCK ON PANCREATIC AND GASTRIC GROWTH IN THE RAT - EFFECT OF CCKA RECEPTOR BLOCKADE", British Journal of Pharmacology, 124(3), 1998, pp. 435-440

Abstract

1 It is now well established that cholecystokinin (CCK) has a major physiological role in the regulation of pancreatic secretion and gastro-intestinal (GI) motility. Both these actions are mediated by stimulation of CCKA-receptors located on pancreatic acini and GI smooth musclecells. While chronic administration of CCK-like peptides invariably causes pancreatic hypertrophy and hyperplasia, their action on gastric growth remains controversial. 2 In the present investigation the action of exogenous and endogenous CCK on both pancreatic and gastric growth was studied in the same animal. In addition, the ability of dexloxiglumide, a new potent and selective CCKA-receptor antagonist, to counteract CCK-mediated effects was evaluated. 3 The amphibian peptide caerulein (1 mu g kg(-1) intraperitoneally three times daily) was used as aCCK agonist, while camostate (200 mg kg(-1) intragastrically once daily), a synthetic protease inhibitor, was used to release endogenous CCK. They were administered to rats for seven days with or without dexloxiglumide (25 mg kg(-1) subcutaneously 15 min before the stimulus). Onthe eighth day, animals were killed, the pancreas and stomach excised, weighed, homogenized and their protein and DNA content measured. 4 Both exogenous and endogenous CCK increased the weight of the pancreas as well as the total pancreatic protein and DNA content. Dexloxiglumide, which alone did not affect pancreatic size and composition, was able to counteract both caerulein-and camostate-induced pancreatic changes. Neither stimuli affected gastric growth in respect of weight and composition of the oxyntic gland area and the antrum. 5 These results show different effects of CCK on pancreatic and gastric growth. The CCK-induced pancreatic hypertrophy and hyperplasia are blocked by the potent and specific CCKA-receptor antagonist, dexloxiglumide. This compound therefore represents a useful tool to investigate CCK-receptor interactions in peripheral organs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 16:19:12