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Titolo:
LIMBIC-CORTICAL NEURONAL DAMAGE AND THE PATHOPHYSIOLOGY OF SCHIZOPHRENIA
Autore:
CSERNANSKY JG; BARDGETT ME;
Indirizzi:
WASHINGTON UNIV,SCH MED,DEPT PSYCHIAT,BOX 8134 ST LOUIS MO 63110 METROPOLITAN ST LOUIS PSYCHIAT CTR ST LOUIS MO 00000
Titolo Testata:
Schizophrenia bulletin
fascicolo: 2, volume: 24, anno: 1998,
pagine: 231 - 248
SICI:
0586-7614(1998)24:2<231:LNDATP>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLASMA HOMOVANILLIC-ACID; SUPERIOR TEMPORAL GYRUS; FIBER SYNAPTIC REORGANIZATION; POSITRON EMISSION TOMOGRAPHY; SEPTAL GLUTAMATERGIC PATHWAY; NUCLEUS-ACCUMBENS NEURONS; BRAIN GLUCOSE-METABOLISM; MAGNETIC-RESONANCE; KAINIC ACID; NEUROLEPTIC TREATMENT;
Keywords:
HIPPOCAMPUS; DOPAMINE; ANTIPSYCHOTIC DRUGS;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Physical, Chemical & Earth Sciences
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
143
Recensione:
Indirizzi per estratti:
Citazione:
J.G. Csernansky e M.E. Bardgett, "LIMBIC-CORTICAL NEURONAL DAMAGE AND THE PATHOPHYSIOLOGY OF SCHIZOPHRENIA", Schizophrenia bulletin, 24(2), 1998, pp. 231-248

Abstract

Neurobiological studies of patients with schizophrenia suggest that abnormalities of both anatomy and function occur in limbic-cortical structures. An anatomical circuit links the functioning of the ventral striatum (i.e., nucleus accumbens) with the hippocampus and other limbic-cortical structures where neurobiological abnormalities have been found. In animals, lesions of Limbic-cortical neurons cause decreases in glutamatergic input to the nucleus accumbens and are also associated with decreases in presynaptic dopamine release, increases in the density of D-2-like dopamine receptors, and insensitivity to the actions of dopamine antagonists such as haloperidol, These experiments suggest a plausible pathophysiology of schizophrenia, in that schizophrenic symptoms may be caused by an abnormal dopaminergic state brought about by a primary limbic-cortical lesion and deficits in glutamatergic inputs to the ventral striatum.

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Documento generato il 17/01/20 alle ore 20:44:35