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Titolo:
DUAL FUNCTIONS OF THE HEARTLESS FIBROBLAST GROWTH-FACTOR RECEPTOR IN DEVELOPMENT OF THE DROSOPHILA EMBRYONIC MESODERM
Autore:
MICHELSON AM; GISSELBRECHT S; ZHOU Y; BAEK KH; BUFF EM;
Indirizzi:
HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DEPT MED,DIV GENET,20 SHATTUCK ST BOSTON MA 02115 HOWARD HUGHES MED INST BOSTON MA 02115
Titolo Testata:
Developmental genetics
fascicolo: 3, volume: 22, anno: 1998,
pagine: 212 - 229
SICI:
0192-253X(1998)22:3<212:DFOTHF>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CELL-MIGRATION; XENOPUS EMBRYOS; TARGETED EXPRESSION; GENE-EXPRESSION; TRANSGENIC MICE; MESSENGER-RNA; FGF; DIFFERENTIATION; PATTERN; MUSCLE;
Keywords:
CELL MIGRATION; FIBROBLAST GROWTH FACTOR; MESODERM; MYOGENESIS; CARDIOGENESIS; RECEPTOR TYROSINE KINASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
90
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Michelson et al., "DUAL FUNCTIONS OF THE HEARTLESS FIBROBLAST GROWTH-FACTOR RECEPTOR IN DEVELOPMENT OF THE DROSOPHILA EMBRYONIC MESODERM", Developmental genetics, 22(3), 1998, pp. 212-229

Abstract

The Drosophila embryonic mesoderm forms by invagination of the ventral-most blastoderm cells. Subsequent development of this germ layer involves the dorsolateral migration of the internalized cells and expansion by cell division, followed by the specification of particular cell fates through the coordinate actions of both intrinsic and extrinsic regulatory mechanisms. The latter include several intercellular signalsthat function across germ layers. These processes combine to generatea diversity of mesodermal subtypes, including the cardial and pericardial cells of the heart or dorsal vessel, a complete set of somatic muscle founders each with its unique identify a population of cells thatform the visceral musculature, and other cells that develop into hemocytes and the fat body. Here, we review recent evidence for the involvement of a Fibroblast growth factor receptor (FGFR) encoded by the heartless (htl) gene in early directional migration of the Drosophila mesoderm. In addition, we provide new data that 1) demonstrate a second role for Htl in promoting the specification of the precursors to certain cardiac and somatic muscle cells in the Drosophila embryo, independent of its cell migration function, 2) suggest that Ras and at least one other signal transduction pathway act downstream of Htl, and 3) establish a functional relationship between the Ras pathway and Tinman (Tin), a homeodomain factor that is essential for specifying some of the same dorsal mesodermal cells that are dependent on Htl. Finally, parallels between requirements for FGFR signaling in Drosophila and vertebrate mesoderm development are considered. (C) 1998 Wiley-Liss, Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 04:21:06