Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
MUTATION ANALYSIS OF THE C-MOS PROTOONCOGENE IN HUMAN OVARIAN TERATOMAS
Autore:
DEFOY KAF; GAYTHER SA; COLLEDGE WH; CROCKETT S; SCOTT IV; EVANS MJ; PONDER BAJ;
Indirizzi:
ADDENBROOKES HOSP,CRC,HUMAN CANC GENET RES GRP,HILLS RD CAMBRIDGE CB22QQ ENGLAND UNIV CAMBRIDGE,PHYSIOL LAB CAMBRIDGE CB2 3EG ENGLAND DERBY CITY GEN HOSP,DEPT OBSTET & GYNAECOL DERBY DE22 3NE ENGLAND UNIV CAMBRIDGE,DEPT GENET CAMBRIDGE CB2 1QR ENGLAND UNIV CAMBRIDGE,WELLCOME CRC INST CAMBRIDGE CB2 1QR ENGLAND
Titolo Testata:
British Journal of Cancer
fascicolo: 10, volume: 77, anno: 1998,
pagine: 1642 - 1644
SICI:
0007-0920(1998)77:10<1642:MAOTCP>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
MOUSE EGGS; PROTOONCOGENE; PRODUCT; GENE; ACTIVATION; CARCINOMA; PHENOTYPE; SEQUENCE; OOCYTES; MICE;
Keywords:
C-MOS; TERATOMA; OVARY; PARTHENOGENESIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
18
Recensione:
Indirizzi per estratti:
Citazione:
K.A.F. Defoy et al., "MUTATION ANALYSIS OF THE C-MOS PROTOONCOGENE IN HUMAN OVARIAN TERATOMAS", British Journal of Cancer, 77(10), 1998, pp. 1642-1644

Abstract

Female transgenic mice lacking a functional c-mos proto-oncogene develop ovarian teratomas, indicating that c-mas may behave as a tumour-suppressor gene for this type of tumour. We have analysed the entire coding region of the c-MOS gene in a series of human ovarian teratomas todetermine whether there are any cancer-causing alterations, DNA from twenty teratomas was analysed by single-strand conformational analysis(SSCA) and heteroduplex analysis (HA) to screen for somatic and germline mutations. In nine of these tumours the entire gene was also sequenced. A previously reported polymorphism and a single new sequence variant were identified. neither of which we would predict to be disease-causing alterations. These results suggest that mutations in the coding region of the c-MOS gene do not play a significant role in the genesis of human ovarian teratomas.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 08:52:04