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Titolo:
LEVEL OF ALPHA-CATENIN EXPRESSION IN COLORECTAL-CANCER CORRELATES WITH INVASIVENESS, METASTATIC POTENTIAL, AND SURVIVAL
Autore:
RAFTOPOULOS I; DAVARIS P; KARATZAS G; KARAYANNACOS P; KOURAKLIS G;
Indirizzi:
UNIV ATHENS,SCH MED,LAIKON HOSP,DEPT PROPEDEUT SURG 2,122 VASILISSIS SOFIAS AVE ATHENS 11526 GREECE UNIV ATHENS,SCH MED,LAB EXPT SURG & SURG RES ATHENS GREECE UNIV ATHENS,SCH MED,DEPT PATHOL ATHENS GREECE
Titolo Testata:
Journal of surgical oncology
fascicolo: 2, volume: 68, anno: 1998,
pagine: 92 - 99
SICI:
0022-4790(1998)68:2<92:LOAEIC>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
E-CADHERIN EXPRESSION; HUMAN GASTRIC-CANCER; L-CAM EXPRESSION; COLON-CARCINOMA; CELL-ADHESION; IMMUNOHISTOCHEMICAL EVALUATION; BETA-CATENIN; LYMPH-NODE; COMPLEX; GROWTH;
Keywords:
ALPHA-CATENIN; COLORECTAL CANCER; DIFFERENTIATION; LYMPH NODE METASTASES; LIVER METASTASES; PROGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
I. Raftopoulos et al., "LEVEL OF ALPHA-CATENIN EXPRESSION IN COLORECTAL-CANCER CORRELATES WITH INVASIVENESS, METASTATIC POTENTIAL, AND SURVIVAL", Journal of surgical oncology, 68(2), 1998, pp. 92-99

Abstract

Background and Objectives: Decreased expression of the E-cadherin/alpha-catenin cell-cell adhesion complex is considered to elicit detachment of tumor cells from primary lesions and development of metastases. The immunohistochemical profile of alpha-catenin in colorectal cancer,as well as its correlation with differentiation, lymph node/liver metastasis and patient survival is presented in this study. Methods: alpha-Catenin expression was investigated with immunohistochemistry technique, in 85 paraffin-embedded and 21 fresh frozen specimens, including 82 colon adenocarcinomas, 10 adenomas, 10 lymph nodes, and 3 liver metastases. Preserved alpha-catenin expression was considered for those tumors that demonstrated more than 90% alpha-catenin(+) cancer cells and reduced alpha-catenin expression for those tumors with less than 90%alpha-catenin(+) cancer cells. The chi(2)-test was used to calculate the statistical correlation of alpha-catenin expression with grade of differentiation and metastatic potential and the log-rank test for thecorrelation with survival rate. Results: Normal mucosa, as well as 8/10 of the colon adenomas, showed strong membranous alpha-catenin expression. Reduced alpha-catenin expression was found in 32/82 (39%) colorectal cancers examined, which was associated with de-differentiation (P < 0.01), lymph node metastasis (P < 0.025), and poor clinical outcome (P < 0.012). alpha-Catenin expression was preserved in 3 liver metastases and their corresponding primary tumors. By contrast, 6/10 of lymphogenous metastases showed decreased alpha-catenin expression. Conclusions: Our findings demonstrate a significant down-regulation of alpha-catenin expression in colorectal cancer which is associated with poordifferentiation, higher metastatic potential and unfavorable prognosis. These preliminary results suggest that alpha-catenin may be a useful marker of invasiveness, metastatic potential, and survival in colorectal cancer patients. (C) 1998 Wiley-Liss, Inc.

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Documento generato il 31/10/20 alle ore 00:40:52