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Titolo:
IDENTIFICATION OF RAT SUSCEPTIBILITY LOCI FOR ADJUVANT-OIL-INDUCED ARTHRITIS
Autore:
LORENTZEN JC; GLASER A; JACOBSSON L; GALLI J; FAKHRAIRAD H; KLARESKOG L; LUTHMAN H;
Indirizzi:
KAROLINSKA HOSP,DEPT MED,RHEUMATOL UNIT,CMM L8 04 S-17176 STOCKHOLM SWEDEN KAROLINSKA HOSP,DEPT MOL MED,ROLF LUFT CTR DIABET RES S-17176 STOCKHOLM SWEDEN
Titolo Testata:
Proceedings of the National Academy of Sciences of the United Statesof America
fascicolo: 11, volume: 95, anno: 1998,
pagine: 6383 - 6387
SICI:
0027-8424(1998)95:11<6383:IORSLF>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; MAJOR HISTOCOMPATIBILITY COMPLEX; CORTICOTROPIN-RELEASING HORMONE; COLLAGEN-INDUCED ARTHRITIS; NON-MHC GENES; DA RATS; LEWIS RATS; CHROMOSOMAL LOCALIZATION; RHEUMATOID-ARTHRITIS; SYNTHETIC ADJUVANT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
48
Recensione:
Indirizzi per estratti:
Citazione:
J.C. Lorentzen et al., "IDENTIFICATION OF RAT SUSCEPTIBILITY LOCI FOR ADJUVANT-OIL-INDUCED ARTHRITIS", Proceedings of the National Academy of Sciences of the United Statesof America, 95(11), 1998, pp. 6383-6387

Abstract

One intradermal injection of incomplete Freund's adjuvant-oil inducesa T cell-mediated inflammatory joint disease in DA rats. Susceptibility genes for oil-induced arthritis (OIA) are located both within and outside the major histocompatibility complex (MHC, Oia1). We have searched for disease-linked non-MHC loci in an F-2 intercross between DA rats and MHC-identical but arthritis-resistant LEW.1AV1 rats. A genome-wide scan with microsatellite markers revealed two major chromosome regions that control disease incidence and severity: Oia2 on chromosome 4(P = 4 x 10(-13)) and Oia3 on chromosome 10 (P = 1 x 10(-6)). All animals homozygous for DA alleles at both loci developed severe arthritis, whereas all those homozygous for LEW.1AV1 alleles were resistant. These results have general implications for situations where nonspecificactivation of the immune system (e.g., incomplete Freund's adjuvant-oil) causes inflammation and disease, either alone or in conjunction with specific antigens. They may also provide clues to the etiology of inflammatory diseases in humans, including rheumatoid arthritis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 20:37:17