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Titolo:
SECRETION OF CYTOKINES BY HUMAN CHOROIDAL MELANOMA-CELLS AND SKIN MELANOMA CELL-LINES IN-VITRO
Autore:
ENZMANN V; FAUDE F; KOHEN L; WEIDEMANN P;
Indirizzi:
UNIV LEIPZIG,DEPT OPHTHALMOL,FAC MED,LIEBIGSTR 10-14 D-04103 LEIPZIG GERMANY
Titolo Testata:
Ophthalmic research
fascicolo: 3, volume: 30, anno: 1998,
pagine: 189 - 194
SICI:
0030-3747(1998)30:3<189:SOCBHC>2.0.ZU;2-I
Fonte:
ISI
Lingua:
ENG
Soggetto:
GROWTH-FACTORS; IN-VITRO; TGF-BETA; INTERLEUKIN-10; EXPRESSION; IL-10; PROLIFERATION; TNF;
Keywords:
CYTOKINES; SKIN MELANOMA CELL LINES; CHOROIDAL MELANOMA; ELISA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
26
Recensione:
Indirizzi per estratti:
Citazione:
V. Enzmann et al., "SECRETION OF CYTOKINES BY HUMAN CHOROIDAL MELANOMA-CELLS AND SKIN MELANOMA CELL-LINES IN-VITRO", Ophthalmic research, 30(3), 1998, pp. 189-194

Abstract

The selective secretion of interleukin 6 (IL-6), interleukin 8 (IL-8), interleukin 10 (IL-10), basic fibroblast growth factor (b-FGF) and transforming growth factor beta 1 (TGF beta-1) in tissue culture of choroidal melanomas and two established skin melanoma cell lines was investigated with ELISA analysis. Values of choroidal melanoma cells were compared with the melanoma cell lines and human fibroblasts as a physiological control. High secretion of IL-6 was detectable in choroidal melanoma cultures but not in the cell lines. IL-8 secretion was found in all melanoma cultures. However, IL-10 was only secreted by one skin melanoma cell line and in choroidal melanoma cell cultures. B-FGF secretion by choroidal melanomas was higher than by cell lines. No differences were seen in the amounts of TGF beta-1 produced by melanoma cells. Human fibroblasts produce higher amounts of IL-6 and IL-8 but lower of b-FGF in vitro in contrast to the melanoma cells. The secretion of cytokines by choroidal melanoma cells suggests an important role of these soluble factors in the interaction of tumour and healthy tissue.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 24/11/20 alle ore 13:48:59