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Titolo:
TUMOR-ASSOCIATED ANTIGENS ARE CYTOKINE INDUCERS AND HYPOREACTIVITY FACTORS TO THE IMMUNE-SYSTEM
Autore:
INGLOT AD; GELDER F; GEORGIADES JA;
Indirizzi:
GEORGIADES FDN TREATMENT CHRON VIRAL DIS STAFFORD TX 77477 GEORGIADES FDN TREATMENT CHRON VIRAL DIS STAFFORD TX 77477 POLISH ACAD SCI,INST IMMUNOL & EXPT THERAPY,VIROL LAB PL-53114 WROCLAW POLAND LOUISIANA STATE UNIV,SCH MED SHREVEPORT LA 71130
Titolo Testata:
Biotherapy
fascicolo: 1, volume: 11, anno: 1998,
pagine: 27 - 37
SICI:
0921-299X(1998)11:1<27:TAACIA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER-ASSOCIATED ANTIGEN; COLORECTAL-CARCINOMA; EXPRESSION; CELLS; VIRUS; INTERFERON; COLOSTRUM; TISSUES; EPITOPE; GICA;
Keywords:
TUMOR ASSOCIATED ANTIGENS; CA 19.9; COLOSTRININ; INTERFERON; TUMOR NECROSIS FACTOR; CYTOKINE INDUCERS; HUMAN LEUKOCYTES; TOLERANCE; ALZHEIMER DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
33
Recensione:
Indirizzi per estratti:
Citazione:
A.D. Inglot et al., "TUMOR-ASSOCIATED ANTIGENS ARE CYTOKINE INDUCERS AND HYPOREACTIVITY FACTORS TO THE IMMUNE-SYSTEM", Biotherapy, 11(1), 1998, pp. 27-37

Abstract

We investigated possible mechanisms leading to the inhibition of the immune system in people with chronic disorders. Tumor cell produce protein released into the circulation, such as tumor associated antigens,may play an important role in processes preceding paralysis of the immune system. To test this hypothesis the following tumor associated antigens were used: AFP, OFF, CA-125, CA-50 and CA-19-9. Their role was assessed by modulating cytokine production in cord blood lymphocytes and peripheral white blood cells obtained from grown population of patients treated with colostrinin, an cytokine inducer. PHA, LPS and colostrinin were used as positive control in those essays. Each antigen tested individually induced IFN, TNF alpha and IL-6 in dose dependent fashion. None of the tested cytokines were spontaneously released by the cells. Data generated from these experiments indicated that tumor associated antigens are inducing type I cytokines in similar fashion as LPS or colostrinin. However, lymphocytes taken from patients undergoing therapy with colostrinin revealed progressive loss capability to produce type 1 cytokines as they did in case of colostrinin. The loss of the capability to respond to antigen may represent phenomenon leading toimmune tolerance.

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Documento generato il 23/09/20 alle ore 13:06:48