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Titolo:
RAT ENDOCRINE PANCREATIC DEVELOPMENT IN RELATION TO 2 HOMEOBOX GENE-PRODUCTS (PDX-1 AND NKX-6.1)
Autore:
OSTER A; JENSEN J; SERUP P; GALANTE P; MADSEN OD; LARSSON LI;
Indirizzi:
STATENS SERUM INST,DEPT MOL CELL BIOL,ARTILLERIVEJ 5,BLDG 81 DK-2300 COPENHAGEN S DENMARK STATENS SERUM INST,DEPT MOL CELL BIOL DK-2300 COPENHAGEN S DENMARK HAGEDORN RES INST GENTOFTE DENMARK
Titolo Testata:
The Journal of histochemistry and cytochemistry
fascicolo: 6, volume: 46, anno: 1998,
pagine: 707 - 715
SICI:
0022-1554(1998)46:6<707:REPDIR>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
HOMEODOMAIN TRANSCRIPTION FACTOR; HUMAN FETAL PANCREAS; ISLET HORMONES; INSULIN GENE; BETA-CELLS; MOUSE PANCREAS; EXPRESSION; POLYPEPTIDE; EPITHELIUM; GLUCAGON;
Keywords:
HOMEODOMAIN PROTEINS; NKX 6.1; PDX-1; INSULIN; PANCREATIC POLYPEPTIDE; GLUCAGON;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
A. Oster et al., "RAT ENDOCRINE PANCREATIC DEVELOPMENT IN RELATION TO 2 HOMEOBOX GENE-PRODUCTS (PDX-1 AND NKX-6.1)", The Journal of histochemistry and cytochemistry, 46(6), 1998, pp. 707-715

Abstract

We studied the distribution of the homeodomain proteins Pdx-1 and Nkx6.1 in the developing rat pancreas. During early development, nuclearstaining for both Pdx-1 and Nkx 6.1 occurred in most epithelial cellsof the pancreatic anlage. Subsequently, Nkx 6.1 became more beta-cell-restricted, and Pdx-1 also occurred in other islet cell types and in the duodenal epithelium. During early pancreatic development, cells co-storing insulin and glucagon were regularly detected. The vast majority of these did not possess nuclear staining for either Pdx-1 or Nkx 6.1. Subsequently, cells storing insulin only appeared. Such cells displayed strongly Pdx-1- and Nkx 6.1-positive nuclei. Therefore, Nkx 6.1,like Pdx-1, may be an important factor in pancreatic development and in mature insulin cell function.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 15/07/20 alle ore 05:30:33