Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
RANDOMIZED PLACEBO-CONTROLLED TRIAL OF DAYTIME FUNCTION AFTER CONTINUOUS POSITIVE AIRWAY PRESSURE (CPAP) THERAPY FOR THE SLEEP APNOEA HYPOPNOEA SYNDROME/
Autore:
ENGLEMAN HM; MARTIN SE; KINGSHOTT RN; MACKAY TW; DEARY IJ; DOUGLAS NJ;
Indirizzi:
ROYAL INFIRM,DEPT MED,LAURISTON PL EDINBURGH EH3 9YW MIDLOTHIAN SCOTLAND UNIV EDINBURGH,RESP MED UNIT EDINBURGH EH8 9YL MIDLOTHIAN SCOTLAND UNIV EDINBURGH,DEPT PSYCHOL EDINBURGH EH8 9YL MIDLOTHIAN SCOTLAND
Titolo Testata:
Thorax
fascicolo: 5, volume: 53, anno: 1998,
pagine: 341 - 345
SICI:
0040-6376(1998)53:5<341:RPTODF>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Soggetto:
APNEA HYPOPNEA SYNDROME; NASAL CPAP;
Keywords:
SLEEP APNEA HYPOPNEA SYNDROME; CONTINUOUS POSITIVE AIRWAY PRESSURE; SLEEPINESS; PSYCHOMOTOR PERFORMANCE; AFFECTIVE DISORDERS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
H.M. Engleman et al., "RANDOMIZED PLACEBO-CONTROLLED TRIAL OF DAYTIME FUNCTION AFTER CONTINUOUS POSITIVE AIRWAY PRESSURE (CPAP) THERAPY FOR THE SLEEP APNOEA HYPOPNOEA SYNDROME/", Thorax, 53(5), 1998, pp. 341-345

Abstract

Background-Patients with the sleep apnoea/hypopnoea syndrome (SAHS) report improved sleepiness, cognitive function, and psychological well being after continuous positive airway pressure (CPAP) therapy, and itis for these daytime features that CPAP is usually given. However, few randomised or controlled studies exist on the effects of CPAP on daytime function. Methods-A prospective, randomised, single blind, placebo controlled, crossover trial of daytime function after CPAP was conducted in 23 patients with SAHS, all with greater than or equal to 15 apnoeas+hypopnoeas/hour and greater than or equal to 2 symptoms of SAHS. All patients spent four weeks on CPAP therapy and four weeks on oral placebo treatment, following randomisation to treatment order. With ethics committee approval, patients were told the placebo tablet might improve upper airway function. Average effective CPAP use was monitoredusing hidden time clocks. Assessments of objective and subjective sleepiness, symptoms, cognitive performance, and psychological well beingwere performed on the last day of each treatment and compared. Results-Objective sleepiness measured by sleep onset latency on the multiplesleep latency test improved with CPAP (mean difference from placebo +2.4 min, 95% CI 0.8 to 4.0; p<0.001) as did subjective sleepiness on the Epworth scale (mean difference -6, 95% CI -3 to -9; p = 0.001). Symptom total score also fell with CPAP (mean difference -1.6, 95% CI -2.2 to -1.0; p<0.001). No determinants of these changes with active treatment were identified, and no significant enhancements to cognitive function or psychosocial well being were found in this small sample. Conclusions-These findings provide further evidence for clinically significant benefits to daytime function from CPAP.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 18/01/20 alle ore 21:32:34