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Titolo:
BIDIRECTIONAL BLOCKADE OF CD4 AND MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II MOLECULES - AN EFFECTIVE IMMUNOSUPPRESSIVE TREATMENT IN THE MOUSE HEART-TRANSPLANTATION MODEL
Autore:
ITO H; HAMANO K; FUKUMOTO T; WOOD KJ; ESATO K;
Indirizzi:
YAMAGUCHI UNIV,SCH MED,DEPT SURG 1,1144 KOGUSHI UBE YAMAGUCHI 755 JAPAN YAMAGUCHI UNIV,SCH MED,DEPT SURG 1 UBE YAMAGUCHI 755 JAPAN
Titolo Testata:
The Journal of heart and lung transplantation
fascicolo: 5, volume: 17, anno: 1998,
pagine: 460 - 469
SICI:
1053-2498(1998)17:5<460:BBOCAM>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
ANTI-CD4 MONOCLONAL-ANTIBODY; CARDIAC ALLOGRAFTS; PERIPHERAL TOLERANCE; GENE-TRANSCRIPTION; INTERFERON-GAMMA; INDUCTION; REJECTION; THERAPY; ANTIGEN; IL-2;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
40
Recensione:
Indirizzi per estratti:
Citazione:
H. Ito et al., "BIDIRECTIONAL BLOCKADE OF CD4 AND MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II MOLECULES - AN EFFECTIVE IMMUNOSUPPRESSIVE TREATMENT IN THE MOUSE HEART-TRANSPLANTATION MODEL", The Journal of heart and lung transplantation, 17(5), 1998, pp. 460-469

Abstract

Background: Anti-CD4 monoclonal antibodies (mabs) are powerful immunosuppressive agents. However, in experimental models anti-CD4 treatmentalone is not always completely effective. Anti-major histocompatibility complex (MHC) class II mabs may have a synergistic effect with anti-CD4 mab therapy by blocking the function of both antigen-presenting cells and T cells. Methods: C3H/He mice (H-2(k): I-A(k), I-E-k) received a vascularized cardiac graft from C57BL/10 (H-2(b): I-A(b)) or BALB/c (H-2(d): I-A(d), I-E-d) mice and were treated with a depleting anti-CD4 or a depleting anti-MHC class II antibody either alone or in combination. Results: Anti-CD4 treatment alone prolonged graft survival in both strain combinations but was only minimally effective when BALB/c donors were used. However, when anti-CD4 and anti-MHC class II mabs were administered together, graft survival was significantly prolonged in both strain combinations. The ratio of interleukin-4 (IL-4)/interferon-gamma (IFN-gamma) expressed in both C57BL/10- and BALB/c-transplanted hearts 7 days after transplantation was significantly higher after combined treatment with anti-CD4 plus anti-MHC class II mabs compared with that found after either treatment alone. Twenty-one days after transplantation, the ratio of IL-4/IFN-gamma in BALB/c hearts after combined mab therapy was significantly lower than at 7 days after transplantation, but in contrast, the cytokine ratio in C57BL/10 hearts remained at an elevated level during the first 21 days after transplantation. Conclusions: These data demonstrate that bidirectional blockade of the antigen-presenting cell and T-cell interaction by use of anti-CD4 and anti-MHC class II mabs in combination is more effective than eithertreatment alone. Graft survival in this model seems to correlate witha prolonged elevation of the IL-4/IFN-gamma ratio in the transplantedheart, suggesting that in this model the induction of unresponsiveness may be associated with a shift toward a Th2-type T-cell response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 16:54:32