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Titolo:
PATHOLOGY OF SPORADIC BREAST-TUMORS WITH LOH AT THE BRCA1 LOCUS - CORRELATION WITH HISTOPATHOLOGICAL FEATURES SPECIFIC TO FAMILIAL BRCA1 TUMORS AND ABSENCE OF MICROSATELLITE INSTABILITY
Autore:
VAURSBARRIERE C; VIDAL V; PENAULTLLORCA F; KWIATKOWSKI F; MAUGARD C; BIGNON YJ;
Indirizzi:
CTR JEAN PERRIN,ONCOL MOL LAB,INSERM CRI 9502,58 RUE MONTALEMBERT,BP 392 F-63011 CLERMONT FERRA 01 FRANCE CTR JEAN PERRIN,ONCOL MOL LAB,INSERM CRI 9502 F-63011 CLERMONT FERRA 01 FRANCE CTR JEAN PERRIN,ONCOL MOL LAB,INSERM F-63011 CLERMONT FERRA 01 FRANCE CTR JEAN PERRIN,ANAT PATHOL LAB F-63011 CLERMONT FERRA 01 FRANCE CTR JEAN PERRIN,LAB ANAL STATIST F-63011 CLERMONT FERRA 01 FRANCE CTR RENE GAUDUCHEAU F-44805 ST HERBELAIN FRANCE
Titolo Testata:
International journal of oncology
fascicolo: 6, volume: 12, anno: 1998,
pagine: 1373 - 1378
SICI:
1019-6439(1998)12:6<1373:POSBWL>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
CANCER SUSCEPTIBILITY GENE; OVARIAN; CARCINOMAS; REGION;
Keywords:
SPORADIC BREAST TUMORS; LOSS OF HETEROZYGOSITY; MICROSATELLITE INSTABILITY; BRCA1;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
C. Vaursbarriere et al., "PATHOLOGY OF SPORADIC BREAST-TUMORS WITH LOH AT THE BRCA1 LOCUS - CORRELATION WITH HISTOPATHOLOGICAL FEATURES SPECIFIC TO FAMILIAL BRCA1 TUMORS AND ABSENCE OF MICROSATELLITE INSTABILITY", International journal of oncology, 12(6), 1998, pp. 1373-1378

Abstract

To investigate the coordinated occurrence of loss of heterozygosity (LOH) at the BRCA1 locus and microsatellite instability (MI) in sporadic breast carcinomas, 56 tumors were analysed for both genetic alterations. The comparison of clinicopathological features with the obtained data revealed that LOH at the BRCA1 locus was significantly correlatedwith features specific for familial BRCA1 tumors and with absence of hormone receptors. No correlation was found between LOH and MI. These results suggest that sporadic and familial breast tumors, where BRCA1 is altered, could display similar clinicopathological features and that LOH and MI are distinct genetic events in sporadic breast carcinogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 14:43:49