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Titolo:
FUNCTIONAL-PROPERTIES OF THE RYANODINE-RECEPTOR-TYPE-3 (RYR3) CA2+ RELEASE CHANNEL
Autore:
SONNLEITNER A; CONTI A; BERTOCCHINI F; SCHINDLER H; SORRENTINO V;
Indirizzi:
SAN RAFFAELE SCI INST,DIBIT I-20132 MILAN ITALY SAN RAFFAELE SCI INST,DIBIT I-20132 MILAN ITALY UNIV LINZ,INST BIOPHYS A-4040 LINZ AUSTRIA UNIV SIENA,SCH MED,DEPT BIOMED SCI I-53100 SIENA ITALY
Titolo Testata:
EMBO journal
fascicolo: 10, volume: 17, anno: 1998,
pagine: 2790 - 2798
SICI:
0261-4189(1998)17:10<2790:FOTR(C>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
CYCLIC ADP-RIBOSE; CHICKEN SKELETAL-MUSCLE; MICE LACKING; CALCIUM-RELEASE; SARCOPLASMIC-RETICULUM; CA2+-RELEASE CHANNEL; ISOFORMS; PROTEIN; BETA; MODULATION;
Keywords:
CA2+-RELEASE CHANNELS; CA2+ SIGNALING; CYCLIC ADENOSINE 5'-DIPHOSPHORIBOSE; RYANODINE RECEPTOR TYPE 3;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
50
Recensione:
Indirizzi per estratti:
Citazione:
A. Sonnleitner et al., "FUNCTIONAL-PROPERTIES OF THE RYANODINE-RECEPTOR-TYPE-3 (RYR3) CA2+ RELEASE CHANNEL", EMBO journal, 17(10), 1998, pp. 2790-2798

Abstract

Single-channel analysis of sarcoplasmic reticulum vesicles prepared from diaphragm muscle, which contains both RyR1 and RyR3 isoforms, revealed the presence of two functionally distinct ryanodine receptor calcium release channels, In addition to channels with properties typical of RyR1 channels, a second population of ryanodine-sensitive channels with properties distinct from those of RyR1 channels was observed. Thenovel channels displayed close-to-zero open-probability at nanomolar Ca2+ concentrations in the presence of 1 mM ATP, but were shifted to the open conformation by increasing Ca2+ to micromolar levels and were not inhibited at higher Ca2+ concentrations. These novel channels weresensitive to the stimulatory effects of cyclic adenosine 5'-diphosphoribose (cADPR), Detection of this second population of RyR channels inlipid bilayers was always associated with the presence of the RyR3 isoform in muscle preparations used for single-channel measurements and was abrogated by the knockout of the RyR3 gene in mice. Based on the above, we associated the novel population of channels with the RyR3 isoform of Ca2+ release channels. The functional properties of the RyR3 channels are in agreement with a potential qualitative contribution of this channel to Ca2+ release in skeletal muscle and in other tissues.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 19:19:13