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Titolo:
CEREBROVASCULAR MUSCLE ATROPHY IS A FEATURE OF ALZHEIMERS-DISEASE
Autore:
PERRY G; SMITH MA; MCCANN CE; SIEDLAK SL; JONES PK; FRIEDLAND RP;
Indirizzi:
CASE WESTERN RESERVE UNIV,INST PATHOL,2085 ADELBERT RD CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT EPIDEMIOL & BIOSTAT CLEVELAND OH 44106 CASE WESTERN RESERVE UNIV,DEPT NEUROL CLEVELAND OH 44106
Titolo Testata:
Brain research
fascicolo: 1-2, volume: 791, anno: 1998,
pagine: 63 - 66
SICI:
0006-8993(1998)791:1-2<63:CMAIAF>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL AMYLOID ANGIOPATHY; PROTEIN; CELLS; DEGENERATION; PRECURSOR;
Keywords:
AMYLOID-BETA; BETA PROTEIN PRECURSOR; HYPOPERFUSION; OXIDATIVE STRESS; VASCULATURE ATROPHY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
G. Perry et al., "CEREBROVASCULAR MUSCLE ATROPHY IS A FEATURE OF ALZHEIMERS-DISEASE", Brain research, 791(1-2), 1998, pp. 63-66

Abstract

We examined vascular amyloid-beta deposition and other abnormalities in the posterior cerebral artery of consecutive cases of Alzheimer's disease (AD) compared to controls. Smooth muscle atrophy was a consistent feature in the cases of AD examined (p < 0.01) and was surprisinglyindependent of adjacent amyloid-beta deposition. These findings suggest that vascular abnormalities are a consistent feature in AD and may be an important contributor to the pathogenesis and complications of AD. (C) 1998 Elsevier Science B.V.

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Documento generato il 27/11/20 alle ore 06:39:38