Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
AN IMMUNOAFFINITY-PURIFIED TRYPANOSOMA-CRUZI ANTIGEN SUPPRESSES CELLULAR PROLIFERATION THROUGH A TGF-BETA-MEDIATED MECHANISM
Autore:
HANSEN DS; VILLACRESERIKSSON M; AKERBLOM L; HELLMAN U; SEGURA E; CARLOMAGNO M; MOREIN B;
Indirizzi:
NATL VET INST,DEPT VIROL,BIOMED CTR BOX 585 S-75123 UPPSALA SWEDEN INST NACL DIAG & INVEST ENFERMEDAD CHAGAS DR MARI BUENOS AIRES DF ARGENTINA SWEDISH UNIV AGR SCI,CTR BIOMED,DEPT VET MED,DIV VIROL UPPSALA SWEDEN BIOMED CTR,LUDWIG INST CANC RES UPPSALA SWEDEN
Titolo Testata:
Scandinavian journal of immunology
fascicolo: 5, volume: 47, anno: 1998,
pagine: 509 - 516
SICI:
0300-9475(1998)47:5<509:AITASC>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN T-CELLS; ALPHA-FETOPROTEIN; HUMAN-LYMPHOCYTES; RECEPTOR EXPRESSION; CYTOKINE PRODUCTION; INFECTION; MICE; INTERLEUKIN-2; ACTIVATION; SURFACE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
38
Recensione:
Indirizzi per estratti:
Citazione:
D.S. Hansen et al., "AN IMMUNOAFFINITY-PURIFIED TRYPANOSOMA-CRUZI ANTIGEN SUPPRESSES CELLULAR PROLIFERATION THROUGH A TGF-BETA-MEDIATED MECHANISM", Scandinavian journal of immunology, 47(5), 1998, pp. 509-516

Abstract

Two subfractions with opposite immunological properties were obtainedfrom the flagellar antigens (FF) of Trypanosoma cruzi epimastigotes by immunoaffinity chromatography. The ligand-bound material (Ag 123) contained four polypeptide bands of 97, 55, 38 and 14 kDa. The nonretained flow-through (FT), induced a potent proliferation of murine naive splenocytes. Ln contrast, Ag 123 inhibited the proliferative capacity of the FT as well as the proliferation mediated by the mitogen Concanavalin A (Con A). The suppressive effect of Ag 123 on the Con A-mediatedproliferation was neutralized by an anti-TGF-beta monoclonal antibody. Both Ag 123 and FF stimulated high serum levels of TGF-beta in injected mice. Ag 123 also induced in vitro secretion of TGF-beta by murinesplenocytes. These results demonstrate that Ag 123 is a potent stimulator of TGF-beta both in vivo and in vitro. Oligopeptides derived fromthe 38 kDa protein present in Ag 123 showed homology with human and rat alpha-fetoproteins (AFP). Ag 123 seems to have a key role in the immunosuppression that develops during early stages in the infection with T. cruzi.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 05:07:50