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Titolo:
A PILOT-STUDY ON CONCURRENT PLATINUM CHEMOTHERAPY AND INTRACAVITARY BRACHYTHERAPY FOR LOCALLY ADVANCED CANCER OF THE UTERINE CERVIX
Autore:
KOUMANTAKIS E; HARALAMBAKIS Z; KOUKOURAKIS M; MAZONAKIS M; HALDEOPOULOS D; PAPAGEORGIOU N; LIVAS V; FROUDARAKIS G; VARVERIS H;
Indirizzi:
IRAKLION UNIV HOSP,DEPT RADIOTHERAPY & ONCOL,POB 1352 IRAKLION 71110 CRETE GREECE IRAKLION UNIV HOSP,DEPT RADIOTHERAPY & ONCOL IRAKLION 71110 CRETE GREECE IRAKLION UNIV HOSP,DEPT OBSTET & GYNECOL IRAKLION 71110 CRETE GREECE IRAKLION UNIV HOSP,DEPT MED PHYS IRAKLION 71110 CRETE GREECE
Titolo Testata:
British journal of radiology
fascicolo: 845, volume: 71, anno: 1998,
pagine: 552 - 557
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIATION-THERAPY; ADVANCED-CARCINOMA; RANDOMIZED TRIAL; RADIOTHERAPY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
E. Koumantakis et al., "A PILOT-STUDY ON CONCURRENT PLATINUM CHEMOTHERAPY AND INTRACAVITARY BRACHYTHERAPY FOR LOCALLY ADVANCED CANCER OF THE UTERINE CERVIX", British journal of radiology, 71(845), 1998, pp. 552-557

Abstract

This study aims to evaluate the feasibility, toxicity and efficacy ofconcurrent chemotherapy with platinum compounds and brachytherapy, for locally advanced carcinoma of the cervix (Stages IIA/B, IIIA). The hypothesis was that synchronous chemo-brachytherapy may be sufficient to cause down-staging of the tumour, to render it operable, and hopefully improve the prognosis. 36 women with locally advanced cervical cancer were treated with concomitant brachytherapy and chemotherapy beforesurgery and/or definitive external radiotherapy All patients receivedtwo caesium-137 Selectron MDR applications, 1 week apart. The dose calculated to point A for each implant was 20-25 Gy. Chemotherapy consisting of continuous cisplatin infusion (50 mg m(2)) and of carboplatin (300 mg m(-2)) was given simultaneously with intracavitary irradiationduring the first and second application, respectively. The combined therapy was followed when feasible by radical hysterectomy, pelvic lymphadenectomy and pelvic radiotherapy. Patients deemed ineligible for surgery because of poor response were given full dose external radiotherapy. 31/36 patients were treated by Wertheim hysterectomy of whom 10 had negative lymph nodes and resection margins. Definitive external radiotherapy was given in the remaining five patients. Overall, 83% were disease free at 2.8 years mean follow-up. The most frequent acute side-effects of chemo-brachytherapy were nausea and vomiting. No renal toxicity was observed. Thrombocytopenia was seen in five patients and wasresponsible for delayed surgery in four patients. Concerning late effects, two patients developed grade 2 intestinal sequelae, two mild frequency and two vaginal stenosis. One rectovaginal and one vesicovaginal fistula developed in two patients; and a third patient had a fistulaassociated with tumour recurrence. Concurrent brachytherapy and chemotherapy with platinum compounds is well tolerated and effective in reducing tumour bulk before definitive local treatment (surgery or external radiotherapy), in patients with locally advanced carcinoma of the uterine cervix.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/09/20 alle ore 19:36:53