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Titolo:
INTERACTIONS BETWEEN N-METHYL-D-ASPARTATE RECEPTOR ANTAGONISTS AND THE DISCRIMINATIVE STIMULUS EFFECTS OF MORPHINE IN RATS
Autore:
BESPALOV AY; BEARDSLEY PM; BALSTER RL;
Indirizzi:
VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOL,POB 613 RICHMOND VA 23298 VIRGINIA COMMONWEALTH UNIV,MED COLL VIRGINIA,DEPT PHARMACOL & TOXICOLRICHMOND VA 23298
Titolo Testata:
Pharmacology, biochemistry and behavior
fascicolo: 2, volume: 60, anno: 1998,
pagine: 507 - 517
SICI:
0091-3057(1998)60:2<507:IBNRAA>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL NERVOUS-SYSTEM; NMDA ANTAGONIST; PHARMACOLOGICAL SPECIFICITY; GLUTAMATE ANTAGONISTS; ANALGESIC TOLERANCE; NUCLEUS-ACCUMBENS; KYNURENIC ACID; C-FOS; MK-801; PHENCYCLIDINE;
Keywords:
MORPHINE; NMDA ANTAGONISTS; NPC17742; DIZOCILPINE; SDZ220-581; ELIPRODIL; HA-966; KYNURENIC ACID; DRUG DISCRIMINATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
71
Recensione:
Indirizzi per estratti:
Citazione:
A.Y. Bespalov et al., "INTERACTIONS BETWEEN N-METHYL-D-ASPARTATE RECEPTOR ANTAGONISTS AND THE DISCRIMINATIVE STIMULUS EFFECTS OF MORPHINE IN RATS", Pharmacology, biochemistry and behavior, 60(2), 1998, pp. 507-517

Abstract

NMDA receptor antagonists have previously been reported to alter somepharmacological and behavioral effects of acute and chronic opioid administration. The present study assessed the interactions of NMDA antagonists with the discriminative stimulus properties of morphine. Adultmale Long-Evans rats were trained to discriminate 3.2 mg/kg of SC morphine from water under a two-lever fixed-ratio 10 schedule of food reinforcement. During test sessions, IP injections of the non-competitiveNMDA receptor antagonist dizocilpine (0.03-0.2 mg/kg), the competitive antagonists NPC 17742 (1-16 mg/kg), and SDZ 220-581 (0.1-3 mg/kg), the polyamine site antagonist eliprodil (3-17.3 mg/kg), the glycine-site partial agonist (+)-HA-966 (3-56 mg/kg), and the nonselective glutamate antagonist kynurenic acid (30-150 mg/kg) were coadministered with SC morphine (1-3.2 mg/kg; interaction tests) or water (generalization tests). In generalization tests, none of the compounds completely substituted for morphine. Concurrent administration of morphine and NMDA antagonists did not greatly alter the discriminative stimulus properties of morphine. Various doses of NPC 17742, SDZ 220-581, or (+)-HA-966 somewhat increased levels of morphine-appropriate lever selection, whereas some attenuation of morphine-lever selection was obtained when morphine was coadministered with eliprodil. These results show that NMDAantagonists have minimal interactions with the discriminative stimulus effects of morphine. (C) 1998 Elsevier Science Inc.

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Documento generato il 10/04/20 alle ore 02:35:28