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Titolo:
EFFECT OF 20 DAYS BED REST ON THE REVERSE CHOLESTEROL TRANSPORT-SYSTEM IN HEALTHY-YOUNG SUBJECTS
Autore:
YANAGIBORI R; KONDO K; SUZUKI Y; KAWAKUBO K; IWAMOTO T; ITAKURA H; GUNJI A;
Indirizzi:
AICHI PREFECTURAL COLL NURSING & HLTH,MORIYAMA KU AICHI 4638502 JAPAN NATL INST HLTH & NUTR TOKYO 162 JAPAN UNIV TOKYO,DEPT HLTH ADM TOKYO JAPAN
Titolo Testata:
Journal of internal medicine
fascicolo: 4, volume: 243, anno: 1998,
pagine: 307 - 312
SICI:
0954-6820(1998)243:4<307:EO2DBR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
ACYLTRANSFERASE LCAT MASS; PHYSICAL-ACTIVITY; PLASMA; LIPOPROTEIN; EXERCISE; LECITHIN; MEN; METABOLISM;
Keywords:
BED REST; CHOLESTEROL ESTER TRANSFER PROTEIN; HDL CHOLESTEROL; LECITHIN-CHOLESTEROL ACYLTRANSFERASE; LIPOPROTEIN LIPASE; TRIGLYCERIDE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
31
Recensione:
Indirizzi per estratti:
Citazione:
R. Yanagibori et al., "EFFECT OF 20 DAYS BED REST ON THE REVERSE CHOLESTEROL TRANSPORT-SYSTEM IN HEALTHY-YOUNG SUBJECTS", Journal of internal medicine, 243(4), 1998, pp. 307-312

Abstract

Objectives. To study the effects of 20 days of bed rest on HDL cholesterol, lipoprotein lipase, hepatic triglyceride lipase, cholesterol ester transfer protein and lecithin-cholesterol acyltransferase. Design. A 20-day intervention study. Setting, Makita general hospital. Subjects. Five male and five female healthy participants, mean age 20.4 years, range 19-24 years. Interventions. Twenty days of bed rest. Main outcome measures. Lipid, lipoprotein, lipoprotein lipase, hepatic triglyceride lipase, cholesterol ester transfer protein and lecithin-cholesterol acyltransferase. Results. Easting HDL, HDL, and HDL, cholesterol levels decreased from 1.748 to 1.404 mmol L-1 (P < 0.01), from 0.807 to0.628 mmol L-1 (P<0.01) and from 0.939 to 0.784mmol L-1 (P < 0.05), respectively, while VLDL triglyceride levels increased from 0.365 to 0.754 mmol L-1 (P < 0.05). Plasma post-heparin lipoprotein lipase activity decreased from 0.494 to 0.418 mu mol mL(-1) h(-1) (P < 0.01), but plasma postheparin hepatic triglyceride lipase activity and cholesterolester transfer protein activity did not change during bed rest. Lecithin-cholesterol acyltransferase activity increased from 72.5 to 84.8 nmol mL(-1) h(-1) (P < 0.001). Conclusions. Twenty days of bed rest induced a decline in HDL cholesterol levels and an increase in VLDL triglyceride levels. When considering lipoprotein lipase, hepatic triglyceride lipase, cholesterol ester transfer protein and lecithin-cholesterol acyltransferase as factors in the decreased HDL cholesterol, the contribution of lipoprotein lipase is suggested.

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Documento generato il 28/09/20 alle ore 04:15:46