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Titolo:
EFFECT OF GRANULOCYTE-COLONY-STIMULATING FACTOR (G-CSF) IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PATIENTS - INCREASE IN NUMBERS OF NAIVE CD4 CELLS AND CD34 CELLS MAKES G-CSF A CANDIDATE FOR USE IN GENE-THERAPYOR TO SUPPORT ANTIRETROVIRAL THERAPY
Autore:
NIELSEN SD; AFZELIUS P; DAMLARSEN S; NIELSEN C; NIELSEN JO; MATHIESEN L; HANSEN JES;
Indirizzi:
UNIV COPENHAGEN,HVIDOVRE HOSP,INFECT DIS LAB,DEPT INFECT DIS,144 DK-2650 HVIDOVRE DENMARK UNIV COPENHAGEN,HVIDOVRE HOSP,INFECT DIS LAB,DEPT INFECT DIS DK-2650 HVIDOVRE DENMARK STATENS SERUM INST,RETROVIRUS LAB DK-2300 COPENHAGEN DENMARK
Titolo Testata:
The Journal of infectious diseases
fascicolo: 6, volume: 177, anno: 1998,
pagine: 1733 - 1736
SICI:
0022-1899(1998)177:6<1733:EOGF(I>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-CELLS; REGENERATION; EXPRESSION; SUBSETS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
S.D. Nielsen et al., "EFFECT OF GRANULOCYTE-COLONY-STIMULATING FACTOR (G-CSF) IN HUMAN IMMUNODEFICIENCY VIRUS-INFECTED PATIENTS - INCREASE IN NUMBERS OF NAIVE CD4 CELLS AND CD34 CELLS MAKES G-CSF A CANDIDATE FOR USE IN GENE-THERAPYOR TO SUPPORT ANTIRETROVIRAL THERAPY", The Journal of infectious diseases, 177(6), 1998, pp. 1733-1736

Abstract

The potential of granulocyte colony-stimulating factor (G-CSF) to mobilize CD4 cells and/or CD34 cells for use in gene therapy or to support antiretroviral therapy was examined, Ten human immunodeficiency virus-infected patients were treated with G-CSF (300 mu g/day) for 5 days. Numbers of CD4 and CD34 cells were measured. To examine the numbers of naive and memory type CD4 cells, CD4 cell coexpression of CD45RA andCD45RO was measured. Functionality of mobilized CD4 cells was examined by use of the proliferation assay and interleukin-2 ELISA, The number of CD34 cells increased from 1.50 to 20.01/mu L (P < .002). The CD4 cell count increased from 236 to 452/mu L (P < .002), The CD45RA/CD45RO ratio increased from 0.50 to 0.57 (P < .03), Mobilized CD4 cells were functionally intact. In conclusion, G-CSF induced increases in numbers of CD34 cells and CD4 cells in HIV-infected patients. Furthermore, the fraction of naive CD4 cells increased. These findings have implications for the design of immunotherapy or gene therapy protocols.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 18:13:56