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Titolo:
JC VIRUS REMAINS LATENT IN PERIPHERAL-BLOOD B-LYMPHOCYTES BUT REPLICATES ACTIVELY IN URINE FROM AIDS PATIENTS
Autore:
LAFON ME; DUTRONC H; DUBOIS V; PELLEGRIN I; BARBEAU P; RAGNAUD JM; PELLEGRIN JL; FLEURY HJA;
Indirizzi:
UNIV BORDEAUX 2,VIROL LAB,INST FEDERAT RECH PATHOL INFECT,146 RUE LEOSAIGNAT F-33076 BORDEAUX FRANCE CTR HOSP GEN,SERV MED INTERNE LANGON FRANCE CTR HOSP GEN,SERV PATHOL INFECT LANGON FRANCE CHU BORDEAUX,HOP PELLEGRIN BORDEAUX FRANCE CHU BORDEAUX,HOP HAUT LEVEQUE BORDEAUX FRANCE
Titolo Testata:
The Journal of infectious diseases
fascicolo: 6, volume: 177, anno: 1998,
pagine: 1502 - 1505
SICI:
0022-1899(1998)177:6<1502:JVRLIP>2.0.ZU;2-Z
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROGRESSIVE MULTIFOCAL LEUKOENCEPHALOPATHY; POLYMERASE CHAIN-REACTION; BRAIN-TISSUE; DNA; LEUKOCYTES; INFECTION; DIAGNOSIS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
M.E. Lafon et al., "JC VIRUS REMAINS LATENT IN PERIPHERAL-BLOOD B-LYMPHOCYTES BUT REPLICATES ACTIVELY IN URINE FROM AIDS PATIENTS", The Journal of infectious diseases, 177(6), 1998, pp. 1502-1505

Abstract

JC virus (JCV) is thought to reach the central nervous system by a vascular route. To determine whether JCV is conveyed in peripheral bloodas latent or reactivated virus, blood leukocytes, plasma, and urine from 50 AIDS patients and plasma and B lymphocytes from 60 AIDS patients were investigated. Peripheral blood from 88 human immunodeficiency virus-negative blood donors was studied. Nested polymerase chain reaction assays allowed the identification of JCV T DNA and VPI mRNAs. The latter indicate viral replication. Blood harbored JCV DNA in 31.8% of AIDS patients (only 2.3% of blood donors; P > .001) and urine in 56%. VPI mRNAs were detected in blood of 1 AIDS patient. Notably, 38% of DNA-positive urine samples and 10 cerebrospinal fluid samples (CSF) from AIDS patients with progressive multifocal leukoencephalopathy contained JCV mRNAs. Thus, JCV was significantly more frequent in blood from AIDS patients than from controls, but, in most instances, it was latent, whereas active replication was detected in urine and CSF.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 18:04:59