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Titolo:
PROLONGATION OF ALLOGRAFT SURVIVAL BY ADMINISTRATION OF MAB SPECIFIC FOR THE 3 SUBUNITS OF IL-2 RECEPTOR
Autore:
YASUDA K; NEMOTO T; OHASHI Y; SATOMI S; MURATA K; ISHII N; TAKESHITA T; SUGAMURA K;
Indirizzi:
TOHOKU UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,AOBA KU SENDAI MIYAGI 98077 JAPAN TOHOKU UNIV,SCH MED,DEPT MICROBIOL & IMMUNOL,AOBA KU SENDAI MIYAGI 98077 JAPAN TOHOKU UNIV,SCH MED,DEPT SURG 2,AOBA KU SENDAI MIYAGI 98077 JAPAN
Titolo Testata:
International immunology
fascicolo: 5, volume: 10, anno: 1998,
pagine: 561 - 567
SICI:
0953-8178(1998)10:5<561:POASBA>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
NATURAL-KILLER-CELLS; SEVERE COMBINED IMMUNODEFICIENCY; HEMATOPOIETIC PROGENITOR CELLS; ACUTE REJECTION EPISODES; COMMON GAMMA-CHAIN; T-CELL; INTERLEUKIN-2 RECEPTOR; MONOCLONAL-ANTIBODY; BETA-CHAIN; GROWTH-FACTOR;
Keywords:
ALLOGRAFT; IL-2 RECEPTOR;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
45
Recensione:
Indirizzi per estratti:
Citazione:
K. Yasuda et al., "PROLONGATION OF ALLOGRAFT SURVIVAL BY ADMINISTRATION OF MAB SPECIFIC FOR THE 3 SUBUNITS OF IL-2 RECEPTOR", International immunology, 10(5), 1998, pp. 561-567

Abstract

The IL-2 receptor (IL-2R)gamma chain, the so-called common gamma (gamma(c)) chain, which is shared with multiple cytokine receptors, plays important roles in the immune system, Here we assessed the immunosuppressive ability of mAb specific for the gamma(c) chain in induction of cytotoxic T lymphocytes (CTL) and allograft rejection in combination with mAb specific for the alpha and beta chains of IL-2R, CBA/N (H-2(k)) mice were injected i.p. with allogeneic splenocytes from BALB/c (H-2(d)) mice, and then administered with combinations of anti-IL-2R alpha, anti-IL-2R beta and anti-gamma(c) mAb or a control mAb, Addition of anti-gamma(c) mAb together with anti-IL-2R alpha and anti-IL-2R beta mAb induced a complete inhibition of CTL response. The numbers and populations of CD4(+)CD8(-) and CD4(-)CD8(+) T cells were not significantly affected by administration of the three anti-IL-SR mAb, whereas NK cells were completely depleted in spleens of mice treated with the anti-IL-2R mAb, Furthermore, skin allograft survival was also significantly prolonged by administration of the three anti-IL-2R mAb, These results suggest that the anti-gamma(c) mAb in combination with anti-IL-2R alpha and anti-IL-2R beta mAb is capable of suppressing induction of CTL and NK cells, resulting in prolongation of skin allograft survival.

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Documento generato il 04/07/20 alle ore 14:42:39