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Titolo:
BIOSAFETY MONITORING OF PATIENTS RECEIVING INTRACEREBRAL INJECTIONS OF MURINE RETROVIRAL VECTOR PRODUCER CELLS
Autore:
LONG ZF; LI LP; GROOMS T; LOCKEY C; NADER K; MYCHOVSKY I; MUELLER S; BURIMSKI I; RYAN P; KIKUCHI G; ENNIST D; MARCUS S; OTTO E; MCGARRITY G;
Indirizzi:
GENET THERAPY INC,938 CLOPPER RD GAITHERSBURG MD 20878
Titolo Testata:
Human gene therapy
fascicolo: 8, volume: 9, anno: 1998,
pagine: 1165 - 1172
SICI:
1043-0342(1998)9:8<1165:BMOPRI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
THYMIDINE KINASE GENE; EXPERIMENTAL BRAIN-TUMORS; IN-VIVO; THERAPY; VIRUS; TRANSDUCTION; GANCICLOVIR; PRIMATES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
Z.F. Long et al., "BIOSAFETY MONITORING OF PATIENTS RECEIVING INTRACEREBRAL INJECTIONS OF MURINE RETROVIRAL VECTOR PRODUCER CELLS", Human gene therapy, 9(8), 1998, pp. 1165-1172

Abstract

Patients with recurrent malignant brain cancer, who were receiving gene therapy by intracerebral injection of murine retroviral vector producer cells (VPCs), were monitored for the presence of replication-competent retrovirus (RCR), RCR sequences were not detected by polymerase chain reaction (PCR) in any of the 608 peripheral blood leukocyte (PBL) samples analyzed, Vector DNA sequences were detected transiently in PBL samples from a subset of 34 patients. Humoral immune responses to a retroviral core protein p30 and murine VPC were detected in some patients, most frequently in patients receiving repeated administrations of VPC, RCR was not detected in biological assays of PBLs from 41 patients who had either anti-retroviral antibodies in sera and/or vector DNA in PBLs. Our data suggest that in situ generation of RCR was not detected following intracerebral inoculation of VPCs in any of the 128 patients evaluated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/07/20 alle ore 09:00:14