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Titolo:
NOVEL THIAZOLIDINEDIONE DERIVATIVES WITH RETINOID SYNERGISTIC ACTIVITY
Autore:
EBISAWA M; KAWACHI E; FUKASAWA H; HASHIMOTO Y; ITAI A; SHUDO K; KAGECHIKA H;
Indirizzi:
UNIV TOKYO,GRAD SCH PHARMACEUT SCI,BUNKYO KU,7-3-1 HONGO TOKYO 1130033 JAPAN UNIV TOKYO,GRAD SCH PHARMACEUT SCI,BUNKYO KU TOKYO 1130033 JAPAN UNIV TOKYO,INST MOL & CELLULAR BIOSCI,BUNKYO KU TOKYO 1130032 JAPAN INST MED MOL DESIGN,BUNKYO KU TOKYO 1130033 JAPAN
Titolo Testata:
Biological & pharmaceutical bulletin
fascicolo: 5, volume: 21, anno: 1998,
pagine: 547 - 549
SICI:
0918-6158(1998)21:5<547:NTDWRS>2.0.ZU;2-P
Fonte:
ISI
Lingua:
ENG
Soggetto:
LEUKEMIA-CELLS; DIFFERENTIATION; LIGAND; INDUCTION; GAMMA; J(2);
Keywords:
THIAZOLIDINEDIONE; RETINOID; CELL DIFFERENTIATION; SYNERGIST;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
M. Ebisawa et al., "NOVEL THIAZOLIDINEDIONE DERIVATIVES WITH RETINOID SYNERGISTIC ACTIVITY", Biological & pharmaceutical bulletin, 21(5), 1998, pp. 547-549

Abstract

Several arylmethylidene thiazolidinediones were synthesized and theirretinoidal activities were examined. TZ181 (7a), having a benzanilideskeleton, exhibited differentiation-inducing activity in :HL-60 cell assay, while TZ191 (7b), the N-methylated analog of TZ181 (7a), TZ245 (9) and TZ335 (10) acted as retinoid synergists like the RXR-selectiveligand, LGD1069 (5).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/01/20 alle ore 06:15:02