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Titolo:
POTENT RETINOID SYNERGISTS WITH A DIPHENYLAMINE SKELETON
Autore:
OHTA K; TSUJI M; KAWACHI E; FUKASAWA H; HASHIMOTO Y; SHUDO K; KAGECHIKA H;
Indirizzi:
UNIV TOKYO,GRAD SCH PHARMACEUT SCI,BUNKYO KU,7-3-1 HONGO TOKYO 1130033 JAPAN UNIV TOKYO,GRAD SCH PHARMACEUT SCI,BUNKYO KU TOKYO 1130033 JAPAN UNIV TOKYO,INST MOL & CELLULAR BIOSCI,BUNKYO KU TOKYO 1130032 JAPAN
Titolo Testata:
Biological & pharmaceutical bulletin
fascicolo: 5, volume: 21, anno: 1998,
pagine: 544 - 546
SICI:
0918-6158(1998)21:5<544:PRSWAD>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROMYELOCYTIC LEUKEMIA; CANCER PREVENTION; ACID RECEPTORS; DIFFERENTIATION; CELLS; INDUCTION; THERAPY; LIGAND;
Keywords:
RETINOID; RETINOIC ACID; SYNERGIST; CELL DIFFERENTIATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
K. Ohta et al., "POTENT RETINOID SYNERGISTS WITH A DIPHENYLAMINE SKELETON", Biological & pharmaceutical bulletin, 21(5), 1998, pp. 544-546

Abstract

hydro-5,5,8,8-tetramethyl-2-naphthyl)amino]benzoic acid (5) exhibitedweak retinoidal and retinoid synergistic activities in HL-60 cell differentiation assay, N-Alkylation of 5 caused decrease or loss of differentiation-inducing activity, but enhanced the synergistic activity with a synthetic retinoid Am80 (2), as reflected in the potent synergistic EC50 (SEC50) values of DA023 (11, 1.6 x 10(-10) M) and DA113 (14, 1.4 x 10(-10) M.) in the presence of 1.0 x 10(-10) M Am80 (2).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 00:58:51