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Titolo:
ROLE OF A SUBDOMINANT H-2K(D)-RESTRICTED SV40 TUMOR-ANTIGEN CYTOTOXICT-LYMPHOCYTE EPITOPE IN TUMOR REJECTION
Autore:
NEWMASTER RS; MYLIN LM; FU TM; TEVETHIA SS;
Indirizzi:
PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT MICROBIOL & IMMUNOL H107,500 UNIV DR HERSHEY PA 17033 PENN STATE UNIV,MILTON S HERSHEY MED CTR,COLL MED,DEPT MICROBIOL & IMMUNOL H107 HERSHEY PA 17033
Titolo Testata:
Virology
fascicolo: 2, volume: 244, anno: 1998,
pagine: 427 - 441
SICI:
0042-6822(1998)244:2<427:ROASHS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
AMINO-ACID-RESIDUES; SIMIAN VIRUS-40; TRANSGENIC MICE; TRANSPLANTATION IMMUNITY; SV40-TRANSFORMED CELLS; MEDIATED CYTOTOXICITY; RECOGNITION EPITOPES; SYNTHETIC PEPTIDE; ANCHOR RESIDUES; POINT MUTATIONS;
Keywords:
TUMOR IMMUNITY; ANTIGEN PRESENTATION; CTL; SV40 TUMOR ANTIGEN; SUBDOMINANT CTL EPITOPE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
77
Recensione:
Indirizzi per estratti:
Citazione:
R.S. Newmaster et al., "ROLE OF A SUBDOMINANT H-2K(D)-RESTRICTED SV40 TUMOR-ANTIGEN CYTOTOXICT-LYMPHOCYTE EPITOPE IN TUMOR REJECTION", Virology, 244(2), 1998, pp. 427-441

Abstract

SV40-transformed mKSA cells (H-2(d)) readily induce progressively growing tumors in adult syngeneic BALB/c mice while expressing the full complement of H-2(d) MHC class I antigens. BALB/c mice previously immunized with SV40, soluble SV40 T antigen, or irradiated SV40-transformedsyngeneic, allogeneic, or xenogeneic cells reject an mKSA tumor challenge even though these mice have been considered low-or nonresponders to T antigen due to difficulty in demonstrating SV40 T antigen-specific CTL. We have investigated the role of H-2(d)-restricted CTL in the rejection of SV40 tumors in BALB/c mice. Immunization of BALB/c mice with SV40 induced T antigen-specific CTL which were largely H-2L(d)-restricted. However, following repeated in vitro restimulation with mKSA cells, CTL emerged which recognized a subdominant H-2K(d)-restricted epitope corresponding to T antigen residues 499-507. Immunization of BALB/c mice with a recombinant vaccinia virus expressing the T499-507 epitope provided partial protection against a challenge of syngeneic mKSAtumor cells and induced the generation of T409-507-specific CTL. These results indicate that a subdominant H-2K(d)-restricted CTL epitope can participate in the rejection of SV40 tumors in BALB/c mice. (C) 1998 Academic Press.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 15:27:10