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Titolo:
MOSQUITO FEEDING-INDUCED ENHANCEMENT OF CACHE VALLEY VIRUS (BUNYAVIRIDAE) INFECTION IN MICE
Autore:
EDWARDS JF; HIGGS S; BEATY BJ;
Indirizzi:
TEXAS A&M UNIV,COLL VET MED,DEPT VET PATHOBIOL COLLEGE STN TX 77843 COLORADO STATE UNIV,ARTHROPOD BORNE & INFECT DIS LAB FT COLLINS CO 80523
Titolo Testata:
Journal of medical entomology
fascicolo: 3, volume: 35, anno: 1998,
pagine: 261 - 265
SICI:
0022-2585(1998)35:3<261:MFEOCV>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
FLY LUTZOMYIA-LONGIPALPIS; LA-CROSSE VIRUS; SALIVARY-GLANDS; BORRELIA-BURGDORFERI; AEDES-TRISERIATUS; INBRED STRAINS; TRANSMISSION; ENCEPHALITIS; DISEASE; MALFORMATIONS;
Keywords:
CACHE VALLEY VIRUS; VECTOR-ENHANCED INFECTION; MOUSE MODEL;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
J.F. Edwards et al., "MOSQUITO FEEDING-INDUCED ENHANCEMENT OF CACHE VALLEY VIRUS (BUNYAVIRIDAE) INFECTION IN MICE", Journal of medical entomology, 35(3), 1998, pp. 261-265

Abstract

Cache Valley (CV) virus, an arthropod-borne bunyavirus, recently has emerged as a significant veterinary pathogen causing infertility and congenital malformations in North American ruminants. To investigate the role of vector feeding on CV infection, adult mice were injected subcutaneously with CV, CV and vector thorax extract (a source of vector saliva), or CV into the site of intense, noninfected-mosquito feeding. Mice did not become infected after injection of CV or CV and vector saliva, nor did they produce antibodies to CV. However, injection of CVinto sites of mosquito feeding resulted in viremia and production of anti-CV antibody by 2 wk after infection. This enhancement of CV infection resulted after feeding by Aedes triseriatus (Say),Ae. aegypti (L.), or Culex pipiens (L.). Enhancement occurred when injection was delayed up to 4 h after mosquito feeding, but it was not observed when virus injection was performed at a site distant from mosquito feeding. These results indicate that arbovirus infection may be enhanced by mosquito-vertebrate host interactions and that replication of arboviruses in arthropod vectors may not be responsible for increased virulence of infections mediated by infected arthropods. Enhanced CV infection in pregnant mice did not result in infertility or malformed pups, indicating that the mouse is not a suitable model to study CV-induced malformations.

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Documento generato il 04/04/20 alle ore 21:40:57