Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
NEUROPROTECTION BY NOVEL ANTAGONISTS AT THE NMDA RECEPTOR-CHANNEL ANDGLYCINE(B) SITES
Autore:
WENK GL; BAKER LM; STOEHR JD; HAUSSWEGRZYNIAK B; DANYSZ W;
Indirizzi:
UNIV ARIZONA,ARIZONA RES LABS,DIV NEURAL SYST MEMORY & AGING,384 LIFESCI N BLDG TUCSON AZ 85724 MIDWESTERN UNIV,ARIZONA COLL OSTEOPATH MED,DEPT PHYSIOL PHOENIX AZ 00000 MERZ,DEPT PHARMACOL D-60318 FRANKFURT GERMANY
Titolo Testata:
European journal of pharmacology
fascicolo: 2-3, volume: 347, anno: 1998,
pagine: 183 - 187
SICI:
0014-2999(1998)347:2-3<183:NBNAAT>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; NUCLEUS BASALIS; TOXICITY; NEURONS; MK-801; ACID;
Keywords:
NUCLEUS BASALIS MAGNOCELLULARIS; ACETYLCHOLINE; NEUROPROTECTION; GLYCINE(B) RECEPTOR SITE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
G.L. Wenk et al., "NEUROPROTECTION BY NOVEL ANTAGONISTS AT THE NMDA RECEPTOR-CHANNEL ANDGLYCINE(B) SITES", European journal of pharmacology, 347(2-3), 1998, pp. 183-187

Abstract

Glutamate may act via an N-methyl-D-Aspartate (NMDA)-sensitive receptor site to destroy cholinergic neurons within the nucleus basalis magnocellularis in age-associated neurodegenerative diseases. Multiple interesting properties of the NMDA receptor are relevant to its excitotoxic actions, e.g., glutamate is ineffective unless a glycine (gly) modulatory site is also occupied. Thus, the antagonism of glutamate receptor-related toxicity by blockade of either the NMDA-sensitive recognition site or the gly binding site may therefore have therapeutic applications. The current study investigated the ability of four novel noncompetitive antagonists at these two sites: one NMDA open channel antagonist (MRZ 2/579: 1-amino-1,3,3,5,5-pentamethyl-cyclohexane hydrochloride), and three gly(B) receptor antagonists (MRZ 2/570: 8-bromo-4-hydroxy-1-oxo-1,2-dihydropyridaziono [4,5-beta] quinoline-5-oxide choline salt; MRZ 2/57: 8-fluoro-4-hydroxy-1-oxo-1,2-dihydropyridaziono [4,5-beta] quinoline-5-oxide choline; MRZ 2/576: o-4-hydroxy-1-oxo-1,2-dihydropyridaziono[4,5-beta] quinoline-5-oxide choline) administered acutely,to provide neuroprotection from a NMDA receptor agonist within the nucleus basalis magnocellularis of young rats. Injection of NMDA into the nucleus basalis magnocellularis significantly decreased cortical choline acetyltransferase activity. Acute administration (i.p.) of MRZ 2/579, 2/570, 2/571 and 2/576 provided significant neuroprotection from NMDA. (C) 1998 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 14:47:27