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Titolo:
SYNTHESIS OF (1-[C-11]METHYL-2(S)-PYRROLIDINYL)METHOXY]PYRIDINE AND (1-[C-11]METHYL-2(R)-PYRROLIDINYL)METHOXY]PYRIDINE - RADIOLIGANDS FOR IN-VIVO STUDIES OF NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS
Autore:
KASSIOU M; RAVERT HT; MATHEWS WB; MUSACHIO JL; LONDON ED; DANNALS RF;
Indirizzi:
NIDA,DIV INTERNAL RES,BRAIN IMAGING SECT,POB 5180 BALTIMORE MD 21224 JOHNS HOPKINS MED INST,DEPT RADIOL,DIV NUCL MED BALTIMORE MD 21205
Titolo Testata:
Journal of labelled compounds & radiopharmaceuticals
fascicolo: 5, volume: 39, anno: 1997,
pagine: 425 - 431
SICI:
0362-4803(1997)39:5<425:SO(A(>2.0.ZU;2-S
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIVING HUMAN-BRAIN; IN-VIVO; BINDING-SITES; DIVERSITY; EPIBATIDINE; TOMOGRAPHY; DEMENTIA; DOPAMINE; AGONIST; PET;
Keywords:
NICOTINIC ACETYLCHOLINE RECEPTORS; 3-PYRIDYL ETHERS; POSITRON EMISSION TOMOGRAPHY; C-11;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
M. Kassiou et al., "SYNTHESIS OF (1-[C-11]METHYL-2(S)-PYRROLIDINYL)METHOXY]PYRIDINE AND (1-[C-11]METHYL-2(R)-PYRROLIDINYL)METHOXY]PYRIDINE - RADIOLIGANDS FOR IN-VIVO STUDIES OF NEURONAL NICOTINIC ACETYLCHOLINE-RECEPTORS", Journal of labelled compounds & radiopharmaceuticals, 39(5), 1997, pp. 425-431

Abstract

1-[C-11]Methyl-2(S)-pyrrolidinyl)methoxy]pyridine, [C-11]A-84543, a selective radioligand for neuronal nicotinic acetylcholine receptors (nAChRs) was prepared by N-alkylation of N-desmethyl A-84543 with [C-11]methyl iodide in DMF. The radioligand was purified by semipreparative reverse-phase HPLC. The average specific radioactivity was 1755 mCi/mumol calculated at end-of-synthesis (EOS). The average time of synthesis, including formulation, was 17 min. The pharmacologically less active (R) enantiomer, 3-[(1-[C-11]methyl-2(R)-pyrrolidinyl) methoxy]pyridine was synthesized in an analogous manner using the appropriate N-desmethyl precursor. The specific radioactivity wascalculated to be 2368 mCi/mu mol (EOS).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 12:46:00