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Titolo:
PERONEAL NERVE NEUROPATHY IN CANCER-PATIENTS - A PARANEOPLASTIC-SYNDROME
Autore:
KOEHLER PJ; BUSCHER M; ROZEMAN CAM; LEFFERS P; TWIJNSTRA A;
Indirizzi:
DE WEVER & GREGORIUS HOSP,DEPT NEUROL & CLIN NEUROPHYSIOL,POB 4446 NL-6401 CX HEERLEN NETHERLANDS UNIV HOSP MAASTRICHT,DEPT NEUROL NL-6202 AZ MAASTRICHT NETHERLANDS UNIV LIMBURG,DEPT EPIDEMIOL NL-6200 MD MAASTRICHT NETHERLANDS
Titolo Testata:
Journal of neurology
fascicolo: 5, volume: 244, anno: 1997,
pagine: 328 - 332
SICI:
0340-5354(1997)244:5<328:PNNIC->2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
CACHEXIA;
Keywords:
PERONEAL NEUROPATHY; NEOPLASM; PARANEOPLASTIC SYNDROME; WEIGHT LOSS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
11
Recensione:
Indirizzi per estratti:
Citazione:
P.J. Koehler et al., "PERONEAL NERVE NEUROPATHY IN CANCER-PATIENTS - A PARANEOPLASTIC-SYNDROME", Journal of neurology, 244(5), 1997, pp. 328-332

Abstract

Aims: To investigate the occurrence of symptomatic peroneal neuropathy (PN) in cancer patients, as well as that of cancer in PN patients and to seek possible factors in the aetiology of PN. Methods: Clinical, neurographical, and myographical data of patients with PN, in two general neurology clinics during a 5-year period (1988-1992) were analysedretrospectively. A population-based cancer registry was consulted forepidemiological data in the area. Results: The catchment population of the two clinics consisted of 433,142 people, and 8,766 new cancer patients were diagnosed. PN was diagnosed in 372 patients, of whom 74 suffered from cancer (in 56 PN was believed to be related to cancer). The crude relative risk of PN in patients with cancer compared with patients without cancer was 8.6. After correction for differences in age and sex between the compared groups, the relative risk dropped to 3.4 (2.8 for women and 3.6 for men). The crude relative risk of cancer for patients with PN relative to people without PN was 7.5. The relative risk, after correction for age and sex, was 2.8 (2.5 for women and 2.9 for men). All relative risks were significant (P < 0.001), but did notdiffer between the sexes (P > 0.4). Weight loss was established in 35/56 patients, but in 17/56 it was unknown. PN has not been found to bepart of a polyneuropathy. Chemotherapy did not play a causal part. Insome patients PN preceded the diagnosis of cancer. Conclusions: The occurrence of PN seems to be higher in patients with cancer than in people without cancer. Cancer was found in patients with PN more often, particularly in elderly men, than would be expected from the occurrencein the total population. PN in patients with cancer is supposed to bedue to a combination of metabolic and mechanical factors. The findings justify a prospective study of the relation between PN and cancer.

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Documento generato il 01/12/20 alle ore 00:56:04