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Titolo:
TRANSLATION-INVARIANT ORIENTATION TUNING IN VISUAL COMPLEX CELLS COULD DERIVE FROM INTRADENDRITIC COMPUTATIONS
Autore:
MEL BW; RUDERMAN DL; ARCHIE KA;
Indirizzi:
UNIV SO CALIF,DEPT BIOMED ENGN,MAIL CODE 1451 LOS ANGELES CA 90089 UNIV SO CALIF,NEUROSCI PROGRAM LOS ANGELES CA 90089
Titolo Testata:
The Journal of neuroscience
fascicolo: 11, volume: 18, anno: 1998,
pagine: 4325 - 4334
SICI:
0270-6474(1998)18:11<4325:TOTIVC>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
CAT STRIATE CORTEX; RANDOM DOT PATTERNS; NEOCORTICAL PYRAMIDAL NEURONS; RECEPTIVE-FIELD PROPERTIES; ACTION-POTENTIALS; CORTICAL-NEURONS; DENDRITIC MORPHOLOGY; APICAL DENDRITES; AREA 17; RESPONSES;
Keywords:
COMPLEX CELLS; ORIENTATION TUNING; ACTIVE DENDRITES; SINGLE NEURON COMPUTATION; VISUAL CORTEX; ENERGY MODELS; COMPUTATIONAL MODELS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
68
Recensione:
Indirizzi per estratti:
Citazione:
B.W. Mel et al., "TRANSLATION-INVARIANT ORIENTATION TUNING IN VISUAL COMPLEX CELLS COULD DERIVE FROM INTRADENDRITIC COMPUTATIONS", The Journal of neuroscience, 18(11), 1998, pp. 4325-4334

Abstract

Hubel and Wiesel (1962) first distinguished ''simple'' from ''complex'' cells in visual cortex and proposed a processing hierarchy in whichrows of LGN cells are pooled to drive oriented simple cell subunits, which are pooled in turn to drive complex cells. Although parsimoniousand highly influential, the pure hierarchical model has since been challenged by results indicating that many complex cells receive excitatory monosynaptic input from LGN cells or do not depend on simple cell input. Alternative accounts of complex cell orientation tuning remain scant, however, and the function of monosynaptic LGN contacts onto complex cell dendrites remains unknown. We have used a biophysically detailed compartmental model to investigate whether nonlinear integration of LGN synaptic inputs within the dendrites of individual pyramidal cells could contribute to complex-cell receptive field structure. We show that an isolated cortical neuron with ''active'' dendrites, driven only by excitatory inputs from overlapping ON-and OFF-center LGN subfields, can produce clear phase-invariant orientation tuning-a hallmark response characteristic of a complex cell. The tuning is shown to depend critically both on the spatial arrangement of LGN synaptic contacts across the complex cell dendritic tree, established by a Hebbian developmental principle, and on the physiological efficacy of excitatory voltage-dependent dendritic ion channels. We conclude that unoriented LGN inputs to a complex cell could contribute in a significant way to its orientation tuning, acting in concert with oriented inputs to the same cell provided by simple cells or other complex cells. As such, our model provides a novel, experimentally testable hypothesis regarding the basis of orientation tuning in the complex cell population, and more generally underscores the potential importance of nonlinear intradendritic subunit processing in cortical neurophysiology.

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Documento generato il 11/07/20 alle ore 14:24:19