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Titolo:
KIR2.4 - A NOVEL K+ INWARD RECTIFIER CHANNEL ASSOCIATED WITH MOTONEURONS OF CRANIAL NERVE NUCLEI
Autore:
TOPERT C; DORING F; WISCHMEYER E; KARSCHIN C; BROCKHAUS J; BALLANYI K; DERST C; KARSCHIN A;
Indirizzi:
MAX PLANCK INST BIOPHYS CHEM,AM FASSBERG 11 D-37070 GOTTINGEN GERMANY MAX PLANCK INST BIOPHYS CHEM D-37070 GOTTINGEN GERMANY UNIV GOTTINGEN,INST PHYSIOL D-37073 GOTTINGEN GERMANY UNIV MARBURG,INST NORMAL & PATHOL PHYSIOL D-35033 MARBURG GERMANY
Titolo Testata:
The Journal of neuroscience
fascicolo: 11, volume: 18, anno: 1998,
pagine: 4096 - 4105
SICI:
0270-6474(1998)18:11<4096:K-ANKI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
RECTIFYING POTASSIUM CHANNEL; THYROTROPIN-RELEASING-HORMONE; FUNCTIONAL EXPRESSION; RAT-BRAIN; MOLECULAR-CLONING; XENOPUS OOCYTES; HUMAN HIPPOCAMPUS; MESSENGER-RNAS; PROTEIN; RECTIFICATION;
Keywords:
INWARDLY RECTIFYING; KIR2; IRK4; MOTONEURONS; IN SITU HYBRIDIZATION; HYPOGLOSSAL NUCLEUS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
C. Topert et al., "KIR2.4 - A NOVEL K+ INWARD RECTIFIER CHANNEL ASSOCIATED WITH MOTONEURONS OF CRANIAL NERVE NUCLEI", The Journal of neuroscience, 18(11), 1998, pp. 4096-4105

Abstract

Members of the Kir2 subfamily of inwardly rectifying K+ channels characterized by their strong current rectification are widely expressed both in the periphery and in the CNS in mammals. We have cloned from rat brain a fourth subfamily member, designated Kir2.4 (IRK4), which shares 53-63% similarity to Kir2.1, Kir2.2, or Kir2.3 on the amino acid level. In situ hybridization analysis identifies Kir2.4 as the most restricted of all Kir subunits in the brain. Kir2.4 transcripts are expressed predominantly in motoneurons of cranial nerve motor nuclei withinthe general somatic and special visceral motor cell column and thus are uniquely related to a functional system. Heterologous expression ofKir2.4 in Xenopus oocytes and mammalian cells gives rise to low-conductance channels (15 pS), with an affinity to the channel blockers Ba2(K-i = 390 mu M) and Cs+ (K-i = 8.06 mM) 30-50-fold lower than in other Kir channels. Low Ba2+ sensitivity allows dissection of Kir2.4 currents from other Kir conductances in hypoglossal motoneurons (HMs) in rat brainstem slices. The finding that Ba2+-mediated block of Kir2.4 inHMs evokes tonic activity and increases the frequency of induced spike discharge indicates that Kir2.4 channels are of major importance in controlling excitability of motoneurons in situ.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 10:10:06