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Titolo:
ASSESSMENT OF THE ACTIVITY OF TACALCITOL ON PSORIATIC PLAQUES BY MEANS OF COLORIMETRY AND HIGH-FREQUENCY ULTRASOUND - A DOUBLE-BLIND INTRASUBJECT HALF-SIDE RIGHT-LEFT COMPARISON WITH BETAMETHASONE VALERATE ANDPLACEBO
Autore:
SEIDENARI S; MAGNI R; GIANNETTI A;
Indirizzi:
UNIV MODENA,DEPT DERMATOL,VIA POZZO 71 I-41100 MODENA ITALY
Titolo Testata:
Skin pharmacology
fascicolo: 1, volume: 10, anno: 1997,
pagine: 40 - 47
SICI:
1011-0283(1997)10:1<40:AOTAOT>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
SKIN-THICKNESS; BLOOD-FLOW; 1-ALPHA,25-DIHYDROXYVITAMIN-D3; DIFFERENTIATION; VITAMIN-D3;
Keywords:
TACALCITOL; PSORIASIS; ULTRASOUND; ECHOGRAPHY; IMAGE ANALYSIS; COLORIMETRY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
S. Seidenari et al., "ASSESSMENT OF THE ACTIVITY OF TACALCITOL ON PSORIATIC PLAQUES BY MEANS OF COLORIMETRY AND HIGH-FREQUENCY ULTRASOUND - A DOUBLE-BLIND INTRASUBJECT HALF-SIDE RIGHT-LEFT COMPARISON WITH BETAMETHASONE VALERATE ANDPLACEBO", Skin pharmacology, 10(1), 1997, pp. 40-47

Abstract

The aim of our study was to further investigate and to objectively assess the effects of tacalcitol on psoriasis by means of double-blind comparisons with placebo and betamethasone valerate, documented by instrumental evaluation. The study was conducted as intrasubject half-sideright-left comparisons. Twelve subjects entered a double-blind placebo-controlled treatment (tacalcitol/placebo group), whereas 14 subjectsreceived double-blind medication with tacalcitol/betamethasone valerate. Medications were applied once daily without occlusion to affected skin areas. Instrumental evaluations were carried out by means of a colorimeter and a 20-MHz B scanner. The colour co-ordinate a, representing the colour range from green (-) to red (+), was used for assessingerythema. B scan images were processed according to segmentation procedures. A 0-10 interval, marking the hyporeflecting dermal areas, was used for assessing oedema and inflammatory infiltration at psoriatic plaque sites. Twenty-two patients (11 of the tacalcitol/betamethasone group and 11 of the tacalcitol/ placebo group) completed the treatment period. Mean a values showed an increase in the tacalcitol/betamethasone group after the first week of therapy on both sides, followed by aslight decrease, the values of which did not reach statistical relevance for either treatment. The decrease observed at tacalcitol-treated sites in patients of the tacalcitol/placebo group was not significant either with respect to baseline values during the first weeks of therapy. The extension of 0-10 dermal areas decreased both in betamethasone- and tacalcitol-treated areas in both patient groups. No significant differences were noticeable between the two treatments at all assessment points, although both by clinical and echographic evaluation a morepronounced decrease in clinical scores and in echogenicity values wasobservable at betamethasone-valerate-treated sites, especially at weeks 6 and 8. According to our data, assessment of erythema does not always represent a valid method for monitoring the response to therapy inpsoriatic patients. In fact, modifications of a values did not allowa distinction between different treatments, whereas processing of echographic images by the 0-10 segmentation enabled tacalcitol to be classified as a topical drug, the activity of which approaches that of a potent steroid.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 16/07/20 alle ore 19:00:06