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Titolo:
NONMYOGENIC FACTORS BIND NICOTINIC ACETYLCHOLINE-RECEPTOR PROMOTER ELEMENTS REQUIRED FOR RESPONSE TO DENERVATION
Autore:
BESSEREAU JL; LAUDENBACH V; LEPOUPON C; CHANGEUX JP;
Indirizzi:
INST PASTEUR,DEPT BIOTECHNOL,CNRS,UA D1284,25-28 RUE DR ROUX F-75724 PARIS 15 FRANCE INST PASTEUR,DEPT BIOTECHNOL,CNRS,UA D1284 F-75724 PARIS 15 FRANCE
Titolo Testata:
The Journal of biological chemistry
fascicolo: 21, volume: 273, anno: 1998,
pagine: 12786 - 12793
SICI:
0021-9258(1998)273:21<12786:NFBNAP>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-SUBUNIT GENE; MUSCLE-SPECIFIC EXPRESSION; TRANSCRIPTION FACTOR USF; PREFERENTIAL SYNAPTIC EXPRESSION; MOUSE SKELETAL-MUSCLE; ELECTRICAL-ACTIVITY; MYOGENIC FACTORS; NEUROMUSCULAR-JUNCTION; TRANSGENIC MICE; E-BOX;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
47
Recensione:
Indirizzi per estratti:
Citazione:
J.L. Bessereau et al., "NONMYOGENIC FACTORS BIND NICOTINIC ACETYLCHOLINE-RECEPTOR PROMOTER ELEMENTS REQUIRED FOR RESPONSE TO DENERVATION", The Journal of biological chemistry, 273(21), 1998, pp. 12786-12793

Abstract

Nicotinic acetylcholine receptors (AChRs) belong to a class of muscleproteins whose expression is regulated by muscle electrical activity. In innervated muscle fiber, AChR genes are transcriptionally repressed outside of the synapse, while after denervation they become reexpressed throughout the fiber. The myogenic determination factors (MDFs) ofthe MyoD family have been shown to play a central role in this innervation-dependent regulation. In the chicken AChR alpha-subunit gene promoter, two E-boxes that bind MDFs are necessary to achieve the enhancement of transcription following muscle denervation. However, the deletion of promoter sequences located upstream to these E-boxes greatly impairs the response to denervation (Bessereau, J, L,, Stratford-Perricaudet, L, D,, Piette, J,, Le Poupon, C, and Changeux, J, P, (1994) Proc. Natl Acad. Sci, U, S, A. 91, 1304-1308), Here we identified two additional cia-regulatory elements of the alpha-subunit gene promoter thatcooperate with the E-boxes in the denervation response. One region binds the Sp1 and Sp3 zinc finger transcription factors. The second region binds at least three distinct factors, among which we identified anupstream stimulatory factor, a b-ZIP-HLH transcription factor. We propose that among MDF-responsive muscle promoters, a specific combination between myogenic and nonmyogenic factors specify innervation-dependent versus innervation-independent promoters.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/11/20 alle ore 14:26:15