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Titolo:
APOLIPOPROTEIN E4 IN PARKINSON-DISEASE AND DEMENTIA - NEW DATA AND METAANALYSIS OF PUBLISHED STUDIES
Autore:
INZELBERG R; CHAPMAN J; TREVES TA; ASHEROV A; KIPERVASSER S; HILKEWICZ O; VERCHOVSKY R; KLIMOWITZKY S; KORCZYN AD;
Indirizzi:
HILLEL YAFFE MED CTR IL-38100 HADERA ISRAEL TEL AVIV UNIV,DEPT NEUROL,TEL AVIV MED CTR,SACKLER FAC MED RAMAT AVIVISRAEL
Titolo Testata:
Alzheimer disease and associated disorders
fascicolo: 1, volume: 12, anno: 1998,
pagine: 45 - 48
SICI:
0893-0341(1998)12:1<45:AEIPAD>2.0.ZU;2-0
Fonte:
ISI
Lingua:
ENG
Soggetto:
E ALLELE EPSILON-4; ONSET ALZHEIMERS-DISEASE; LEWY BODY; E GENOTYPES; ASSOCIATION;
Keywords:
APOLIPOPROTEIN E; DEMENTIA; GENOTYPING; METAANALYSIS; PARKINSONS DISEASE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
R. Inzelberg et al., "APOLIPOPROTEIN E4 IN PARKINSON-DISEASE AND DEMENTIA - NEW DATA AND METAANALYSIS OF PUBLISHED STUDIES", Alzheimer disease and associated disorders, 12(1), 1998, pp. 45-48

Abstract

The authors examined whether the epsilon 4 allele might be associatedwith dementia in Parkinson disease (PD), given that the dementia of PD shares neuroanatomic and neurochemical features with Alzheimer disease (AD) and that many recent studies have found a high prevalence of the epsilon 4 allele of apolipoprotein E (ApoE) in AD. The authors examined patients with PD (n = 125, 47 demented) and unrelated controls (n= 93) using a short mental test. DNA was obtained from blood leukocytes. The relevant portion of the apolipoprotein E (ApoE) gene was amplified by polymerase chain reaction, and the epsilon 4 allele was identified using B restriction enzyme. The frequency of the ApoE epsilon 4 allele in demented patients with PD (14%) was not greater than that in nondemented patients (17%), whereas patients with PD as a whole showeda trend toward a higher epsilon 4 allele frequency (16%) than age-matched controls (10%, p = 0.07). The epsilon 4 allele frequency in nondemented patients with PD was significantly higher than in controls (p =0.055). These results and the meta-analysis of four published reportsfail to support the hypothesis that the epsilon 4 allele is associated with dementia in PD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 19/09/20 alle ore 08:11:05