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Titolo:
SERIAL PRECISION OF METABOLITE PEAK AREA RATIOS AND WATER REFERENCED METABOLITE PEAK AREAS IN PROTON MR SPECTROSCOPY OF THE HUMAN BRAIN
Autore:
SIMMONS A; SMAIL M; MOORE E; WILLIAMS SCR;
Indirizzi:
INST PSYCHIAT,DEPT CLIN NEUROSCI,NEUROIMAGING RES GRP,DE CRESPIGNY PKLONDON SE5 8AF ENGLAND
Titolo Testata:
Magnetic resonance imaging
fascicolo: 3, volume: 16, anno: 1998,
pagine: 319 - 330
SICI:
0730-725X(1998)16:3<319:SPOMPA>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MAGNETIC-RESONANCE SPECTROSCOPY; TEMPORAL-LOBE EPILEPSY; NMR-SPECTROSCOPY; MULTIPLE-SCLEROSIS; HEPATIC-ENCEPHALOPATHY; ABSOLUTE QUANTITATION; N-ACETYLASPARTATE; CANAVANS DISEASE; INVIVO; QUANTIFICATION;
Keywords:
MRS; QUANTITATION; MAGNETIC RESONANCE SPECTROSCOPY; PRECISION; IN VIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
A. Simmons et al., "SERIAL PRECISION OF METABOLITE PEAK AREA RATIOS AND WATER REFERENCED METABOLITE PEAK AREAS IN PROTON MR SPECTROSCOPY OF THE HUMAN BRAIN", Magnetic resonance imaging, 16(3), 1998, pp. 319-330

Abstract

The precision of cerebral proton magnetic resonance spectroscopy (MRS) measurements is critical both in the clinical setting and for research purposes. Marshall et al. have recently concluded that ''disappointing in vivo repeatability...is likely to limit'' the ability of MRS todetect modest changes. We present here a comprehensive study of the precision of short-and long-term metabolite peak area ratios and water referenced metabolite peak areas for long echo time point resolved spectroscopy (PRESS) spectra (repetition time (TR) = 2000 ms, echo time (TE) = 136 ms) acquired from the occipital lobes of normal volunteers and a phantom using a conventional whole body 1.5 T MR system and conventional acquisition and analysis protocols. Short-term in vitro precision determined by five repeat scans on five occasions was excellent asmeasured by a mean coefficient of variation (NAA/Cho = 1.3%, NAA/Cr PCr = 1.0%, Cho/Cr + PCr = 1.6%, NAA/H2O = 0.5%, Cho/H2O = 1.2%, Cr PCr/H2O = 0.8%). Long term in vitro precision using 100 spectra acquired over 2 years was also very good (NAA/Cho = 2.7%, NAA/Cr + PCr = 1.4%, Cho/Cr + PCr = 2.2%, NAA/H2O = 1.5%, Cho/H2O = 2.4%, Cr + PCr/H2O = 1.5%). Short-term in vivo precision determined by five repeat scans in a single scanning session on eight subjects was also excellent (NAA/Cho = 5.2%, NAA/Cr + PCr = 3.0%, Cho/Cr + PCr = 6.6%, NAA/H2O = 1.4%,Cho/H2O = 4.9%, Cr + PCr/H2O = 2.7%) and only worsened slightly for long-term in vivo precision determined by five repeat scans on eight subjects over 3 months (NAA/Cho = 5.2%, NAA/Cr + PCr = 4.8%, Cho/Cr + PCr = 7.7%, NAA/H2O = 2.5%, Cho/H2O = 6.4%,Cr + PCr/H2O = 3.8%). We attribute the excellent precision reported here to the use of highly automated techniques for voxel shimming, water suppression and peak area measurements. These results allow us to repudiate Marshall's assertion regarding disappointing repeatability of in vivo MRS. (C) 1998 ElsevierScience Inc.

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Documento generato il 01/04/20 alle ore 20:57:35