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Titolo:
IN-VIVO RELAXATION-TIME MEASUREMENTS IN THE HUMAN PLACENTA USING ECHO-PLANAR IMAGING AT 0.5 T
Autore:
GOWLAND PA; FREEMAN A; ISSA B; BOULBY P; DUNCAN KR; MOORE RJ; BAKER PN; BOWTELL RW; JOHNSON IR; WORTHINGTON BS;
Indirizzi:
UNIV NOTTINGHAM,DEPT PHYS,MAGNET RESONANCE CTR,UNIV PK NOTTINGHAM NG72RD ENGLAND
Titolo Testata:
Magnetic resonance imaging
fascicolo: 3, volume: 16, anno: 1998,
pagine: 241 - 247
SICI:
0730-725X(1998)16:3<241:IRMITH>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEAR MAGNETIC-RESONANCE; INVERSION; SEQUENCES; CONTRAST; WEIGHT; SHOT;
Keywords:
RELAXATION TIMES; PLACENTA; FETUS; ECHO-PLANAR IMAGING;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
21
Recensione:
Indirizzi per estratti:
Citazione:
P.A. Gowland et al., "IN-VIVO RELAXATION-TIME MEASUREMENTS IN THE HUMAN PLACENTA USING ECHO-PLANAR IMAGING AT 0.5 T", Magnetic resonance imaging, 16(3), 1998, pp. 241-247

Abstract

This paper presents the first in vivo measurements of the nuclear magnetic resonance relaxation times T-1 and T-2 at 0.5 T in the human placenta from 20 weeks gestational age until term, in both normal and compromised pregnancies. T-1 measurements were performed by using both aninversion recovery sequence and the Look-Locher echo planar imaging (EPI) sequence on a total of 41 women with normal pregnancies and 11 women with compromised pregnancies. T-2 measurements were performed by using a spin-echo EPI sequence on 36 women with normal pregnancies and 14 women with compromised pregnancies. In normal pregnancies, both theT-1 values measured with the inversion recovery sequence and the T-2 values were found to decrease with gestational age, the linear regression results gave T-1 = -9.1t + 1538 r(2) = 0.23 p = 0.03 T-2 = -4.0t 338 r(2) = 0.47 p = 410(-6) where t is the gestational age in weeks, and T-1 and T-2 are the relaxation times in milliseconds. T-1 values measured very rapidly with the Look-Locher EPI sequence, but, therefore, with a much lower signal-to noise ratio, showed no significant trends. The T-1 values measured in the abnormal group were significantly lower than those measured in the normal group. Four out of eight patients with compromised pregnancies had placental T-1 values lying outside the 90% confidence limits for the normal population based about the regression line, significantly more than expected by chance (p = 0.005). Ten out of fourteen of the T-2 measurements in the abnormal group were below the regression line established for the normal group, with 4 lying below the 90% confidence interval, although these trends were only just significant (p = 0.06 and p = 0.03). O 1998 Elsevier Science Inc.

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Documento generato il 02/12/20 alle ore 18:37:20