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Titolo:
MAGNETICALLY LABELED WATER PERFUSION IMAGING OF THE UTERINE ARTERIES AND OF NORMAL AND MALIGNANT CERVICAL TISSUE - INITIAL EXPERIENCES
Autore:
HAWIGHORST H; BOCK M; KNOPP MV; ESSIG M; SCHOENBERG SO; KNAPSTEIN PG; SCHAD LR; VANKAICK G;
Indirizzi:
GERMAN CANC RES CTR,DEPT RADIOL DIAGNOST & THERAPY,NEUENHEIMER FELD 280 D-69120 HEIDELBERG GERMANY
Titolo Testata:
Magnetic resonance imaging
fascicolo: 3, volume: 16, anno: 1998,
pagine: 225 - 234
SICI:
0730-725X(1998)16:3<225:MLWPIO>2.0.ZU;2-9
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR ANGIOGENESIS; PROGNOSTIC FACTOR; BRAIN-TUMORS; CARCINOMA; CHEMOTHERAPY; MAMMOGRAPHY; NECROSIS; LESIONS; BREAST; IMAGES;
Keywords:
UTERINE ARTERIES; CERVIX; ADVANCED CERVICAL CARCINOMA (FIGO IIB-IVA); MAGNETIC RESONANCE; PERFUSION STUDY; MAGNETICALLY LABELED WATER PERFUSION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
H. Hawighorst et al., "MAGNETICALLY LABELED WATER PERFUSION IMAGING OF THE UTERINE ARTERIES AND OF NORMAL AND MALIGNANT CERVICAL TISSUE - INITIAL EXPERIENCES", Magnetic resonance imaging, 16(3), 1998, pp. 225-234

Abstract

Purpose: The aim of this pilot study was to evaluate a magnetically labeled water perfusion imaging technique as a non-contrast-enhanced approach to demonstrate the uterine artery, its branches, and to assess the cervical uterine blood flow in healthy volunteers and in patients with advanced uterine cervical carcinoma (FIGO IIB-IVA). Methods and Materials: Seven healthy volunteers (mean age, 29 years) and twenty-twopatients (mean age, 52 gears) with advanced cancer of the uterine cervix (FIGO IIB-IVA) were prospectively examined by magnetically labeledwater perfusion imaging at different inversion delay times (300-900 ms). The magnetic resonance imaging (MRI) findings of all patients werematched to the findings of contrast-enhanced dynamic MRI and multiplebiopsies (n = 5) and/or surgical whole mount specimens (n = 17), which were available in all patients. Results: The uterine artery was wellvisualized with short inversion delay times of 300-500 ms, It was characterized as single or multiple helical loops before dividing into its intracervical branches, The intracervical branching was observed at inversion delay times of 500-700 ms. With longer inversion delay times, arterial signal enhancement disappeared and cervical tissue enhancement was noted. Enhancement of benign tissue was observed at inversion delay times of 1100-1700 ms and in malignant tissue at shorter inversion delay times of 900-1300 ms. The maximum of this diffuse signal enhancement of benign tissue was seen at inversion delay times of 1500 ms (1100-1700 ms) in malignant tissue at significantly (p < 0.5) shorter inversion delay times of 1100 ms (900-1300 ms). Conclusion: Our preliminary results show that the vascular supply and blood flow of the normal uterine cervix and of advanced cervical cancer can be assessed by magnetically labeled water perfusion imaging and that malignant cervical tissue is earlier and stronger perfused than normal cervical tissue. (C) 1998 Elsevier Science Inc.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/09/20 alle ore 10:38:43