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Titolo:
DIFFERENT MEANING OF CD38 MOLECULE EXPRESSION ON CD4(-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION SURVIVING LONGER THAN 5 YEARS() AND CD8(+) CELLS OF CHILDREN PERINATALLY INFECTED WITH HUMAN)
Autore:
DEMARTINO M; ROSSI ME; AZZARI C; GELLI MG; GALLI L; VIERUCCI A;
Indirizzi:
UNIV CHIETI,DEPT MED,PAEDIAT SECT,VIA VESTINI,COLLE ARA I-66100 CHIETI ITALY UNIV FLORENCE,DEPT PAEDIAT FLORENCE ITALY
Titolo Testata:
Pediatric research
fascicolo: 6, volume: 43, anno: 1998,
pagine: 752 - 758
SICI:
0031-3998(1998)43:6<752:DMOCME>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
CD4+ T-CELLS; HIV-1 INFECTION; HLA-DR; DISEASE PROGRESSION; LYMPH-NODES; ACTIVATION; LYMPHOCYTES; INDIVIDUALS; CYTOKINES; ANTIGENS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
44
Recensione:
Indirizzi per estratti:
Citazione:
M. Demartino et al., "DIFFERENT MEANING OF CD38 MOLECULE EXPRESSION ON CD4(-IMMUNODEFICIENCY-VIRUS TYPE-1 INFECTION SURVIVING LONGER THAN 5 YEARS() AND CD8(+) CELLS OF CHILDREN PERINATALLY INFECTED WITH HUMAN)", Pediatric research, 43(6), 1998, pp. 752-758

Abstract

We investigated the relationship between CD4(+)CD38(+), CD4(+)HLA-DR+, CD8(+)CD38(+), and CD8(+)HLA-DR+ cell proportions (HLA-DR = major histocompatibility complex class II) (determined by two-color immunofluorescence) and the clinical condition, IL-2 and IL-6 production, viral RNA copy numbers, and the eventual immunologic-virologic course in 25 children perinatally infected with HIV-1 surviving longer than 5 y [median age, 92 (range, 63-136) mo]. Twelve healthy age-matched children were studied as control subjects. HIV-1(+) children had lower percentages and absolute numbers of CD4(+)CD38(+) whereas the percentages of CD4(+)HLA-DR+ and the percentages and absolute numbers of CD8(+)CD38(+)and CD8(+)HLA-DR+ cells were higher than that of control subjects. The absolute numbers of CD4(+) and the percentages of CD4(+)CD38(+) CD8()CD38(+), and CD8(+)HLA-DR+ cells directly correlated, whereas the percentages of CD4(+)CD38(+) and CD4(+)HLA-DR+ cells, the percentages ofCD4(+)CD38(+) and CD8(+)CD38(+) cells, the CD8(+) cell absolute numbers, and the percentages of CD8(+)CD38(+) cells did not. Severe manifestations and immunologic deterioration occurred in children with low CD4(+)CD38(+) cell percentages, whereas virologic worsening was associated with low CD8(+)CD38(+) and CD8(+)HLA-DR+ cell percentages. IL-2 production directly correlated with percentages and absolute numbers of CD4(+)CD38(+) and CD8(+)CD38(+) cells. RNA copy numbers inversely correlated with CD4(+)CD38(+), CD4(+)HLA-DR+, CD8(+)CD38(+), and CD8(+)HLA-DR+ cell percentages. This suggests that CD38 molecule expression on both CD4(+) and CD8(+) cell subsets is a favorable marker in HIV-1(+) children. Perhaps CD8(+)CD38(+) subsets are activated cells, whereas CD4(+)CD38(+) subsets are immature cells, possibly the host's attempt atCD4(+) cell renewal.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 04:28:43