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Titolo:
EXPRESSION OF COMPLEMENT RECEPTOR-1 AND RECEPTOR-2 ON FOLLICULAR DENDRITIC CELLS IS NECESSARY FOR THE GENERATION OF A STRONG ANTIGEN-SPECIFIC IGG RESPONSE
Autore:
FANG YF; XU CG; FU YX; HOLERS VM; MOLINA H;
Indirizzi:
WASHINGTON UNIV,SCH MED,DIV RHEUMATOL,DEPT MED,BOX 8045,660 S EUCLID AVE ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DIV RHEUMATOL,DEPT MED ST LOUIS MO 63110 WASHINGTON UNIV,SCH MED,DEPT LAB MED PATHOL,DEPT MED ST LOUIS MO 63110 VET ADM MED CTR ST LOUIS MO 63106 UNIV COLORADO,HLTH SCI CTR,DEPT MED DENVER CO 80262 UNIV COLORADO,HLTH SCI CTR,DEPT IMMUNOL DENVER CO 80262
Titolo Testata:
The Journal of immunology
fascicolo: 11, volume: 160, anno: 1998,
pagine: 5273 - 5279
SICI:
0022-1767(1998)160:11<5273:EOCRAR>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
T-DEPENDENT ANTIGEN; IMMUNE-RESPONSE; ANTIBODY-RESPONSE; MONOCLONAL-ANTIBODIES; CLASSICAL PATHWAY; GERMINAL-CENTERS; LYMPHOCYTES-B; TYPE-1 CR-1; MOUSE; DISTINCT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
42
Recensione:
Indirizzi per estratti:
Citazione:
Y.F. Fang et al., "EXPRESSION OF COMPLEMENT RECEPTOR-1 AND RECEPTOR-2 ON FOLLICULAR DENDRITIC CELLS IS NECESSARY FOR THE GENERATION OF A STRONG ANTIGEN-SPECIFIC IGG RESPONSE", The Journal of immunology, 160(11), 1998, pp. 5273-5279

Abstract

Two mechanisms could account for the impaired humoral immune responsefound in Cr2(-/-) mice. The absence of complement receptors 1 and 2 (CR1, CR2) on B cells could affect their activation Alternatively, impaired Ag trapping by follicular dendritic cells (FDC) could affect B cell maturation into Ig-secreting or memory B cells, To compare the roles of CR1 and CR2 on B cells vs FDC in this abnormal response, bone marrow (BM) chimeric mice were generated and immunized with specific T-dependent Ags, The primary and secondary Ab response was measured. Cr2(+/+) animals reconstituted with a Cr2(-/-) BM generated a diminished but detectable humoral immune response compared with controls. When injected with preformed immune complexes (IC), these mice maintained follicular IC localization. Cr2(-/-) animals reconstituted with a Cr2(+/+) BM had an initial rise in the Ab titer, but were unable to maintain itas shown by a pronounced decrease in the Ige titer, This defect persisted during the secondary immune response. Follicular IC trapping was also impaired. Despite the abnormal Ab response, germinal center formation was retained in all of the chimeric animals. These experiments are the first to demonstrate an absolute requirement for CR1 and CR2 expression on FDC in the generation of a normal humoral immune response.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 00:57:49