Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
CORRECTION OF DEAFNESS IN SHAKER-2 MICE BY AN UNCONVENTIONAL MYOSIN IN A BAC TRANSGENE
Autore:
PROBST FJ; FRIDELL RA; RAPHAEL Y; SAUNDERS TL; WANG AH; LIANG Y; MORELL RJ; TOUCHMAN JW; LYONS RH; NOBENTRAUTH K; FRIEDMAN TB; CAMPER SA;
Indirizzi:
UNIV MICHIGAN,DEPT HUMAN GENET,4701 MSRB 111,1500 W MED CTR DR ANN ARBOR MI 48109 NIDOCD,NIH ROCKVILLE MD 20850 MICHIGAN STATE UNIV,GRAD PROGRAM GENET E LANSING MI 48824 UNIV MICHIGAN,KRESGE HEARING RES INST ANN ARBOR MI 48109 NATL HUMAN GENOME RES INST BETHESDA MD 20892 NIH,INTRAMURAL SEQUENCING CTR ROCKVILLE MD 20850 UNIV MICHIGAN,DNA SEQUENCING CORE FACIL ANN ARBOR MI 48109
Titolo Testata:
Science
fascicolo: 5368, volume: 280, anno: 1998,
pagine: 1444 - 1447
SICI:
0036-8075(1998)280:5368<1444:CODISM>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
HAIR-CELLS; MOUSE; GENE; ALIGNMENT; ACTIN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
F.J. Probst et al., "CORRECTION OF DEAFNESS IN SHAKER-2 MICE BY AN UNCONVENTIONAL MYOSIN IN A BAC TRANSGENE", Science, 280(5368), 1998, pp. 1444-1447

Abstract

The shaker-2 mouse mutation, the homolog of human DFNB3, causes deafness and circling behavior. A bacterial artificial chromosome (BAC) transgene from the shaker-2 critical region corrected the vestibular defects, deafness, and inner ear morphology of shaker-2 mice. An unconventional myosin gene, Myo15, was discovered by DNA sequencing of this BAG. Shaker-2 mice were found to have an amino acid substitution at a highly conserved position within the motor domain of this myosin, Auditory hair cells of shaker-2 mice have very short stereocilia and a long actin-containing protrusion extending from their basal end. This histopathology suggests that Myo15 is necessary for actin organization in the hair cells of the cochlea.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 02/12/20 alle ore 17:53:08